Results 81 to 90 of about 4,687,299 (337)

Oxyresveratrol Attenuates Inflammation in Human Keratinocyte via Regulating NF-kB Signaling and Ameliorates Eczematous Lesion in DNCB-Induced Dermatitis Mice

Pharmaceutics, 2023
Oxyresveratrol (ORV) is one of the novel antioxidants having been extensively studied in recent years. One of the main sources of ORV is Artocarpus lakoocha, which has been used in traditional medicine in Thailand for decades. However, the role of ORV in
Hung Gia Tran, Aussavashai Shuayprom, Patipark Kueanjinda, Asada Leelahavanichkul, Prapai Wongsinkongman, Siriwan Chaisomboonpan, Apiwat Tawatsin, Kriangsak Ruchusatsawat, Jongkonnee Wongpiyabovorn   +8 more
doaj   +1 more source

Anti-inflammation effects of injectable platelet-rich fibrin via macrophages and dendritic cells.

Journal of Biomedical Materials Research. Part A, 2019
Immune response to implantation materials plays a critical role during early local inflammation and biomaterial-induced regeneration or restoration. A novel platelet concentrate termed i-PRF (injectable platelet-rich fibrin) has recently been developed ...
Jinglun Zhang, Chengcheng Yin, Qin Zhao, Zifan Zhao, Jinyang Wang, R. Miron, Yufeng Zhang   +6 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Anti fungal activity of alcoholic extract of Peganum harmala seeds [PDF]

, 2011
In our study, it was aimed to determine antifungal activity of Peganum harmala on medically important yeasts and molds in vitro. Fungal suspensions of Candida spp and aspergillus spp isolated from the clinical specimens were treated with serial dilutions
Diba, K., Khorshivand, Z., Shabatkhori, M., Shoar, M.G.   +3 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease

Nature Communications
Renal tubulointerstitial abnormalities predict diabetic kidney disease (DKD) progression, and targeting them may prevent DKD. Insulin-like growth factor binding-protein 7 (IGFBP7) is expressed in renal tubular cells and is elevated in both blood and ...
Ju-tao Yu, Xiao-wei Hu, Jia-nan Wang, Qin Yang, Xiang-yu Li, Run-run Shan, Tian Pu, Rui Hou, Xiao-yu Shen, Yu-qin Wang, Fei Zhang, Xiao-wen Yu, Jie Wang, Feng-he Li, Jia-gen Wen, Ying Fan, Juan Jin, Yi-yang Jiang, Xiao-ming Meng   +18 more
doaj   +1 more source

Lactylation: the metabolic–immune hub in autoimmune diseases

Frontiers in Immunology
In recent years, lactate modification, as an emerging post-translational modification mechanism, has attracted increasing attention for its role in the regulation of the immune system. Autoimmune diseases are a category of complex disorders characterized
Qingqing Xia, Qingqing Xia, Dantong Sun, Dantong Sun, Ke Wan, Chengcheng Liu, Han Shu, Miao Wang, Tongsheng Zhou, Tongsheng Zhou, Ying Chen, Xue Yang, Xiao-Feng Li, Xiao-Feng Li, Biao Song, Biao Song, Facai Wang, Facai Wang   +17 more
doaj   +1 more source

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

Frontiers in Pharmacology, 2018
Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. Inhibition of PDE4 is predicted to have diverse effects
Heng Li, Heng Li, Jianping Zuo, Jianping Zuo, Wei Tang, Wei Tang, Wei Tang   +6 more
doaj   +1 more source

Age and diabetes related changes of the retinal capillaries: an ultrastructural and immunohistochemical study [PDF]

, 2015
Normal human aging and diabetes are associated with a gradual decrease of cerebral flow in the brain with changes in vascular architecture. Thickening of the capillary basement membrane and microvascular fibrosis are evident in the central nervous system
ARTICO, Marco, BATTAGLIONE, Ezio, BIANCHI, ENRICA, Feher, Janos, Kovacs, Illes, MAGLIULO, Giuseppe, Micera, Alessandra, ORLANDO, Maria Patrizia, PLATEROTI, Rocco, Ripandelli, Guido, TAURONE, SAMANTA   +10 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source