Results 81 to 90 of about 4,511,051 (310)
Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]
, 2010 PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Vascular cell adhesion molecule (VCAM)-1 has garnered significant research attention due to its potential as a disease biomarker and drug target across several inflammatory pathologies—including atherosclerosis, asthma, rheumatoid arthritis, and ...
Ta, Hang Thu +2 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Emerging Roles for G-protein Coupled Receptors in Development and Activation of Macrophages
Frontiers in Immunology, 2019 Macrophages have emerged as a key component of the innate immune system that emigrates to peripheral tissues during gestation and in the adult organism.
Xinming Wang +6 more
doaj +1 more source
Anti-inflammatory diet or anti-inflammatory lifestyle?
Giornale di Clinica Nefrologica e DialisiChronic low-grade inflammation is increasingly proving to be one of the main culprits for the onset of numerous pathologies. Until recently, to try to combat this insidious enemy, we mainly resorted to anti-inflammatory diets, but current scientific evidence seems to support the hypothesis that the maximum impact on health could be obtained above all ...
David Mariani, Sabrina Lucchetti
openaire +2 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Anti-inflammatory, antibacterial and analgesic potential of cocos nucifera linn.: A review
, 2013 At present, approximately 25% of drugs in modern pharmacopoeia are derived from plant sources (phytomedicines) that can be developed for the treatment of diseases and disorders.
Dua, K +4 more
core +1 more source
Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß) [PDF]
, 2015 Gynura procumbens is a medicinal plant, traditionally used to treat inflammation and fever. A yeast-based assay detected GSK3â-inhibitory activity in the aqueous extract of G. procumbens.
Wan Rozianoor Mohd Hassan +6 more
core +1 more source