Results 81 to 90 of about 143,635 (330)

Helicobacter pylori Eradication in Drug-related Peptic Ulcer

open access: yesThe Korean Journal of Gastroenterology, 2020
Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin are the most frequently prescribed drugs worldwide, and their long-term use often leads to peptic ulcers (PUs) along with serious complications, such as bleeding and perforation.
Moon Kyung Joo
doaj   +1 more source

Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents.

open access: yesCurrent drug metabolism, 2006
We hypothesized that aryl acetate- and aryl carboxylate-containing drugs would inhibit human phenol sulfotransferase (SULT1A1), and that selectivity would depend upon the interaction of the aryl portion of the molecule with the sulfotransferase acceptor ...
R. King, Anasuya Ghosh, Jinfang Wu
semanticscholar   +1 more source

Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility

open access: yesAdvanced Science, EarlyView.
Iron overload in ovarian endometriosis (OE) disrupts follicular function and contributes to infertility. This study maps iron‐induced cellular changes using single‐cell and spatial transcriptomics, revealing senescence phenotypes in OE patients and mouse models. Similar patterns are observed in aging ovaries, highlighting iron metabolism as a potential
Yangshuo Li   +14 more
wiley   +1 more source

Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. [PDF]

open access: yes, 2014
Complex interactions between the immune system and the brain might have important aetiological and therapeutic implications for neuropsychiatric brain disorders.
Cousins, Lesley   +5 more
core   +2 more sources

Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein

open access: yesJournal of Inflammation, 2010
The limitations of steroidal and non steroidal anti-inflammatory drugs have prompted investigation into other biologically based therapeutics, and identification of immune selective anti-inflammatory agents of salivary origin.
Befus A Dean   +3 more
doaj   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang   +6 more
wiley   +1 more source

Design and Synthesis of New Non-Steroidal Anti-inflammatory Agents with Expected Selectivity toward Cyclooxygenase-2 Inhibition

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
This study includes design and synthesis of new non-steroidal anti-inflammatory agents (NSAIDs) with expected cyclooxygenase-2 (COX-2) selective inhibition to achieve better activity and low gastric side effects.
Nadeem A. Abdul Razzak   +2 more
doaj   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

open access: yesAdvanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng   +11 more
wiley   +1 more source

Experimental Study of Antimicrobial Properties and Acute Toxicity of the Peo-based Combined Suppositories [PDF]

open access: yes, 2019
Aim. The research of antimicrobial and toxicological parameters of a promising pharmaceutical composition with indole-3-carbinol and meloxicam in the form of rectal suppositories.Materials and methods.
Ravshanov, T. (Tymur)   +4 more
core   +3 more sources

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

open access: yesAdvanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu   +5 more
wiley   +1 more source

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