Results 41 to 50 of about 596,201 (311)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Repositioning drugs for inflammatory disease – fishing for new anti-inflammatory agents

Disease Models & Mechanisms, 2014
Inflammation is an important and appropriate host response to infection or injury. However, dysregulation of this response, with resulting persistent or inappropriate inflammation, underlies a broad range of pathological processes, from inflammatory ...
Christopher J. Hall, Sophie M. Wicker, An-Tzu Chien, Alisha Tromp, Lisa M. Lawrence, Xueying Sun, Geoffrey W. Krissansen, Kathryn E. Crosier, Philip S. Crosier   +8 more
doaj   +1 more source

Mushrooms as a Source of Anti-Inflammatory Agents

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2010
Inflammation is nowadays well known to be involved in the development of several chronic diseases such as arteriosclerosis, obesity, diabetes, neurodegenerative diseases, and cancer. Treatment for chronic inflammatory disorders has not been solved yet, and there is an urgent need to find new and safe anti-inflammatory preventive and therapeutic ...
García - Lafuente, A., Moro, C., Villares Garicochea, Ana, Guillamon, E., Rostagno, M. A., d'Arrigo, M., Martinez, J. A.   +6 more
openaire   +6 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients?

Oman Medical Journal, 2022
Objectives: COVID-19 associated coagulopathy and prophylactic anticoagulant therapy (PAT) are ongoing topics globally. Using PAT for anti-inflammatory effect may prevent thromboembolic events (TEEs).
Sevil Alkan, Alper Şener, Ebru Doğan, Cihan Yüksel, Buse Yüksel   +4 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Anti-inflammatory agents of the carbamoylmethyl ester class: synthesis, characterization, and pharmacological evaluation

Journal of Inflammation Research, 2013
Bassem Sadek,1 Amar Mansuor Hamruoni,2 Abdu Adem1 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, 2Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University of ...
Sadek B, Hamruoni AM, Adem A
doaj  

Phytochemicals as Anti-Inflammatory Agents in Animal Models of Prevalent Inflammatory Diseases

Molecules, 2020
Phytochemicals are known to have anti-inflammatory effects in vitro and in vivo, such as in inflammatory disease model systems. Inflammation is an essential immune response to exogenous stimuli such as infection and injury.
Seong Ah Shin, Byeong Jun Joo, Jun Seob Lee, Gyoungah Ryu, Minjoo Han, Woe Yeon Kim, Hyun Ho Park, Jun Hyuck Lee, Chang Sup Lee   +8 more
doaj   +1 more source

Antinociceptive and Anti-Inflammatory Effects of Geum iranicum Khatamsaz Methanol Extract in Mice [PDF]

Research Journal of Pharmacognosy, 2019
Background and objectives:Traditionally, Geum species from Rosaceae family have been used for treating inflammatory disorders. Geum iranicum Khatamsaz is endemic to Iran.
Nematollah Ahangar, Fatemeh Mirzaee, Maryam Feizbakhsh, Sara Pirhayati, Somayeh Shahani*   +4 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source