Results 71 to 80 of about 1,717,268 (352)

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Anti-inflammatory agents of the carbamoylmethyl ester class: synthesis, characterization, and pharmacological evaluation

Journal of Inflammation Research, 2013
Bassem Sadek,1 Amar Mansuor Hamruoni,2 Abdu Adem1 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, 2Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University of ...
Sadek B, Hamruoni AM, Adem A
doaj  

Chitosan-Cellulose Composite for Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability, and Biocompatibility [PDF]

, 2014
Chitosan (CS), a polysaccharide derived from chitin, the second most abundant polysaccharide, is widely used in the medical world because of its natural and nontoxic properties and its innate ability for antibacterial and hemostasis effects.
Altiok, Anderson, Anderson, Augustine, Aziz, Bordenave, Burkatovskaya, Burkatovskaya, Burkatovskaya, Cai, Cai, Chatelet, Costerton, Dai, Dai, El-Mekawy, Fakhry, Fink, Finkenstadt, Fulton, Ignatova, Ignatova, Jain, Jayakumar, Jayakumar, Kiyozumi, Kloth, Kong, Lee, Miao, Mori, Mori, Naficy, Oliveira, Pinto, Rabea, Rabea, Sandoval, Silva, Silva, Spoering, Terrill, Tran, Varshosaz, Werner, Wu, Xia   +46 more
core   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Hypoglycemic agents and potential anti-inflammatory activity

Journal of Inflammation Research, 2016
Vishal Kothari,1 John A Galdo,2 Suresh T Mathews3 1Department of Nutrition and Dietetics, Boshell Diabetes and Metabolic Diseases Research Program, Auburn University, Auburn, 2Department of Pharmacy Practice, 3Department of Nutrition and Dietetics ...
Kothari V, Galdo JA, Mathews ST
doaj  

Synthesis of Certain Pyrimidine Derivatives as Antimicrobial Agents and Anti-Inflammatory Agents

Molecules, 2010
A variety of novel bicyclic and tricyclic pyrimidine derivatives was obtained via reaction of 6-amino-2-thioxo-1H-pyrimidine-4-one (1) with a different reagents. The antimicrobial and anti-inflammatory activities of some of the synthesized compounds were
Amira Ibrahim Sayed, Samir M. Awad, Mosaad S. Mohamed   +2 more
doaj   +1 more source

The investigation of the effect of ozone therapy on gout in experimental rat models [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
The effect of ozone treatment in experimental rat gout arthritis was investigated. Twenty adult albino male rats were divided into 4 groups: Group 1 (Control) was followed without any medication, Group 2 (Gout control) was injected with a single dose of ...
Ali BİLGE, Murat TÜYSÜZ, Ömür ÖZTÜRK, Yasemen ADALI, Hüseyin Avni EROĞLU, Mustafa MAKAV, Gözde ATİLA USLU, Ramazan TISKAOĞLU   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts

Journal of Pharmacological Sciences, 2022
The objective of the present study was to evaluate the action of the crude hydroalcoholic extract of Piper cubeba fruits and isolated lignans (cubebin, dihydrocubebin, ethylcubebin, hinokinin and methylcubebin) on head and neck cancer cells. We evaluated
Juliana Prado Gusson-Zanetoni, Julliene Stephanie Guaraldi Monteiro da Silva, Thais Bravo Picão, Laila Toniol Cardin, Janesly Prates, Stefanie Oliveira Sousa, Tiago Henrique, Sonia Maria Oliani, Eloiza Helena Tajara, Marcio Luis Andrade e Silva, Nayanne Larissa Cunha, Ana Carolina da Silva Gomes, Rosangela Silva Laurentiz, Flávia Cristina Rodrigues-Lisoni   +13 more
doaj   +1 more source