Results 211 to 220 of about 696,361 (266)

Curcumin-loaded tetrahedral framework nucleic acids reshape intestinal homeostasis in ulcerative colitis by coordinating barrier repair, microbiota reconstruction, and immune modulation. [PDF]

Mater Today Bio
Li M, Yue X, Liu Q, Cui J, Liu Y, Zhao L, Yang L, Liu Z, Li M, Yu J, Sun SK.   +10 more
europepmc   +1 more source

POSS‐PEG‐NHS and GSH Cocrosslink DPAV to Prepare Anticalcification Bioprosthetic Scaffold With Enhanced Reendothelization, Anti‐inflammation, and Anti‐ROS

Advanced Healthcare Materials, EarlyView.
POSS‐PEG‐NHS and GSH cocrosslinked DPAV to prepare a multifunctional anticalcification valve substitute. This modification enhances mechanical properties, hemocompatibility, and re‐endothelialization while promoting anti‐inflammatory M2 macrophage infiltration and reducing calcification.
Yuqing Zhang, Chen Qian, Yingjie He, Jingli Ding, Binhao Zhang, Minghui Zou, Xing Chen, Jinping Zhao, Cuifen Lu, Jinping Liu, Jianliang Zhou   +10 more
wiley   +1 more source

The anti‑inflammatory activity of 2‑iminothiazolidines: the role of PPARγ and M2 macrophage subpopulations. [PDF]

Inflammopharmacology
Mohr ETB, Lubschinski TL, Moro PAM, Benvenutti L, Costa NTC, de Sousa PLPB, Sá MM, Hernandes MZ, Milton FA, Santin JR, Dalmarco EM.   +10 more
europepmc   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Development and evaluation of a propolis, tea tree oil, and jojoba oil nanoemulgel with enhanced antioxidant, anti-inflammatory, and wound-healing activities. [PDF]

Sci Rep
Saad MH, Kandil SM, Farid A, Safwat G, Diab AA, Taha M.   +5 more
europepmc   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Colchicine Inhibits Chemokine Production in Monosodium Urate-Stimulated Innate Immune Cells. [PDF]

ACR Open Rheumatol
Merlo Pich LM, Schlüter T, Sarlea A, Netea MG, Popa C, Joosten LAB.   +5 more
europepmc   +1 more source

SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma. [PDF]

Cancer Res
Uprety A, Judd C, Villella ED, Keller R, Wagner R, Robertson KD, Rodriguez-Blanco J, Barnoud T, Mason FM, Ho TH, de Cubas AA.   +10 more
europepmc   +1 more source

From Phytochemistry to Drug Discovery: A Systematic Review of Multitarget Pharmacology and Lead Compound Prioritization of <i>Piper crocatum</i> Ruiz & Pav. [PDF]

Drug Des Devel Ther
Apriyanti E, Kurnia D, Al-Anshori J, Takaya A.   +3 more
europepmc   +1 more source