Results 101 to 110 of about 26,381,217 (279)

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

An autopsy case of suspected anti-N-methyl-D-aspartate receptor encephalitis

Journal of Forensic Science and Medicine, 2019
N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare type of autoimmune limbic encephalitis. Herein, we report an autopsy case of highly suspected anti-NMDAR encephalitis, based on the patient's past psychiatric history and autopsy findings of ...
Kino Hayashi, Wakako Hikiji, Yohsuke Makino, Hisaomi Suzuki   +3 more
doaj   +1 more source

Data_Sheet_1_Analysis of characteristics of movement disorders in patients with anti-N-methyl-D-aspartate receptor encephalitis.docx

ObjectiveMovement disorders (MDs) are common in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis but are poorly studied. This study aimed to investigate the clinical characteristics of MDs and the clinical differences between patients with and ...
Hongmei Li (51944), Qiang Meng (2853221), Jiajie Chen (386048), Pinyi Zhou (15473209)   +3 more
core   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

CHARACTERISTICS AND OUTCOMES IN PATIENTS WITH ANTI N-METHYL-DASPARTATE RECEPTOR AUTO-IMMUNE ENCEPHALITIS

Pakistan Armed Forces Medical Journal, 2018
Objective: To study characteristics and outcome in patients with anti-N-Methyl-D-Aspartic Receptor encephalitis. Study Design: Retrospective observational cohort.
Syed Onaiz Zulfiqar Anwar, Jahanzeb Liaqat, , Waseem Alamgir, , Waseem Alamgir   +3 more
doaj   +2 more sources

Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis

Frontiers in Neurology, 2019
Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes in Hcy levels in anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis have not been investigated ...
Lizhi Liu, Lizhi Liu, Jie Liang, Qing Liu, Chongliang Luo, Jia Liu, Rong Fan, Zhigang Chen, Yong Chen, Fuhua Peng, Ying Jiang   +10 more
doaj   +1 more source

Anti-N-methyl-D-aspartate receptor encephalitis in China

Neuroimmunology and Neuroinflammation, 2014
N-methyl-D-aspartate receptors (NMDARs) are mainly distributed in the central nervous system, and play important roles in the mechanisms of learning and memory. A newly discovered disease caused by autoantibody to NMDAR has been described, and is called anti-NMDAR encephalitis. Patients with this disease often suffer from mental disorders, seizures and
Li Li, Cheng-Bin Wang, Gang Zhao
openaire   +2 more sources

Anti-N-methyl-d-aspartate receptor encephalitis in a patient with a 7-year history of being diagnosed as schizophrenia: complexities in diagnosis and treatment

, 2015
Chaohua Huang,1,2,4,* Yukun Kang,1,* Bo Zhang,1 Bin Li,1 Changjian Qiu,1 Shanming Liu,1 Hongyan Ren,1,2 Yanchun Yang,1 Xiehe Liu,1 Tao Li,1–3 Wanjun Guo1,21Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People ...
Ren H, Liu X, Huang C, Yang Y, Li T, Qiu C, Guo W, Li B, Liu S, Kang Y, Zhang B   +10 more
core  

Variations of movement disorders in anti-N-methyl-d-aspartate receptor encephalitis: A nationwide study in Taiwan

, 2017
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is one of the most common autoimmune encephalitis that presents with a wide variety of movement disorders. The purpose of our study is to review the manifestations and duration of movement disorders
Duan, Bi-Chun;Weng, Wen-Chin;Lin, Kuang-Lin;Wong, Lee Chin;Li, Sung-Tse;Hsu, Mei-Hsin;Lin, Jainn-Jim;Fan, Pi-Chaun;Lin, Ming-I.;Chiu, Nan-Chang;Lin, Yu-Ching;Wang, Huei-Shyong;Hung, Kun-Long;Lee, Wang-Tso, 范碧娟;李旺祚;翁妏謹   +1 more
core   +1 more source