Results 91 to 100 of about 2,533,954 (307)

ATYPICAL PRESENTATION IN A CASE OF GRANULOMATOSIS WITH POLYANGIITIS [PDF]

Romanian Journal of Rheumatology, 2016
Granulomatosis with polyangiitis (GPA) is part of the anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis, mostly being ANCA-c (anti proteinase 3) positive. Primarily it involves the upper respiratory tract and kidneys having an increased
Cristina Capusa, Ana-Maria Mehedinti, Claudia Toma, Violeta Bojinca   +3 more
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome [PDF]

, 1993
Cytoplasmic islet cell antibodies are well-established predictive markers of IDDM. Although target molecules of ICA have been suggested to be gangliosides, human monoclonal ICA of the immunoglobulin G class (MICA 1-6) produced from a patient with newly ...
Seißler, Jochen, Meinck, Hans-Michael, Wolfahrt, S., Northemann, Wolfgang, Scherbaum, Werner A., Richter, Wiltrud   +5 more
core   +1 more source

Anti-neutrophil cytoplasmic antibodies in small vessel vasculitis:a historical overview [PDF]

, 2023
The history of anti-neutrophil cytoplasmic antibodies (ANCA) starts with an association with glomerulonephritis and is followed by proving that ANCA play a pathogenic role in ANCA-associated vasculitis (AAV).
Damoiseaux, Jan, Potjewijd, Judith, van Beers, Joyce   +2 more
core   +4 more sources

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications

, 1999
Anti-neutrophil cytoplasmic antibodies, as detected by indirect immunofluorescence, have limited diagnostic significance as they occur in a variety of inflammatory disorders.
Kallenberg, GGM, Tervaert, JWC
core   +1 more source

Cholesterol crystal embolism combined Antineutrophil Cytoplasmic Autoantibodies positive:a case report and literature review

Linchuang shenzangbing zazhi, 2015
Objective To report a case of patients with cholesterol crystal embolism combined antineutrophil cytoplasmic autoantibodies positive,in order to increase the awareness of this rare case,avoid misdiagnosis and delayed treatment Methods Review a case of ...
ZHANG Jun, CHEN Shi-zhi
doaj  

Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]

, 2011
Objectives:  Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Susumu Kusunoki, Tio-Gillen, Anne P., Plomp, J.J., Kusunoki, Susumu, Tio-Gillen, A.P., Willison, H.J., Broos, Ludo A.M., Ueda, M., Mark L. Kuijf, Ludo A. M. Broos, Kuijf, Mark L., Jacobs, B.C., Greenshields, Kay N., Jacobs, Bart C., Zitman, F.M.P., Hugh J. Willison, Anne P. Tio-Gillen, Masami Ueda, Kuijf, M.L., Jaap J. Plomp, Kusunoki, S., Greenshields, K.N., Plomp, Jaap J., Femke M. P. Zitman, Broos, L.A.M., Kay N. Greenshields, Ken-ichi Kaida, Willison, Hugh J., Bart C. Jacobs, Kaida, Ken Ichi, Kaida, K.I., Ueda, Masami, Zitman, Femke M.P.   +32 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source