Results 71 to 80 of about 2,533,954 (307)

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

Advanced Materials, EarlyView.
By growing a conformal ZIF‐8 protective layer directly on antibody‐functionalized microneedles, this work converts a fragile biosensing interface into a thermostable diagnostic platform. The MOF@MN patch enables minimally invasive NGAL detection from dermal ISF while supporting cold‐chain‐independent storage and transport for decentralized kidney ...
Yixuan Wang, Ying Liu, Avishek Debnath, Chuang Li, Zheyu Wang, Gayathri Kondepati, Saketh Balmoori, Jeremiah J. Morrissey, Ying Maggie Chen, Limei Tian, Srikanth Singamaneni   +10 more
wiley   +1 more source

Incidentally Diagnosed Alport Syndrome in a Patient with Drug-Induced Vasculitis

Case Reports in Nephrology, 2019
A 53-year-old woman is admitted with a serum creatinine of 16 mg/dl. Seven months earlier, she was diagnosed with heart failure and started on several medications, including Hydralazine.
D. Lai, N. Dave, R. Raghavan
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Correlation between serum soluble CD206 and disease activity in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis [PDF]

Zhenduanxue lilun yu shijian
Objective This study aims to investigate the expression characteristics of serum soluble CD206 (sCD206) in patients with anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (AGN) and its value in assessing disease activity ...
WEI Zhaonan, AN Xiaoning, NI Liyan, SHEN Pingyan, SHI Hao, ZHANG Wen, CHEN Yongxi
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

A case of microscopic polyangiitis with interstitial pneumonia after coronavirus disease-2019 infection, evidenced by positivity for multiple autoantibodies

Respiratory Medicine Case Reports
Anti-neutrophil cytoplasmic antibody-associated vasculitis is triggered by infection, dust exposure, and drugs. A 73-year-old male presented with dyspnea. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection was confirmed upon admission.
Naoto Arai, Toshikazu Takasaki, Masashi Bando, Kei Yaoita, Yutaro Ueki, Shu Hisata, Makoto Maemondo   +6 more
doaj   +1 more source

Cytoplasmic-anti-neutrophil cytoplasmic antibodies targeting myeloperoxidase in Wegener′s granulomatosis: A rare phenomenon

Indian Journal of Pathology and Microbiology, 2014
Wegener′s granulomatosis (WG) patients can rarely have antineutrophil cytoplasmic antibodies (ANCAs) directed against myeloperoxidase (MPO), producing a cytoplasmic pattern on indirect immunofluorescence (IIF).
Bhavana M Venkatesh, Sangeeta Joshi, Ranjeeta Adhikary   +2 more
doaj   +1 more source

Autoantibodies in Wilson disease: Impact on clinical course

JIMD Reports, 2022
Symptoms of Wilson disease (WD) vary and additional factors such as autoimmunity may play an important role in WD pathogenesis. The presence of antinuclear antibodies (ANA), anti‐neutrophil cytoplasmic antibodies, neuronal surface antibodies, and ...
Magdalena Antczak‐Kowalska, Anna Członkowska, Ceren Eyileten, Anna Palejko, Agnieszka Cudna, Marta Wolska, Agnieszka Piechal, Tomasz Litwin   +7 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source