Results 61 to 70 of about 6,193 (199)

Anti-migration Effect of Aaptos suberitoides Fraction in HCT-116 Colorectal Cancer Cell Line [PDF]

, 2021
Background: Colorectal cancer is the second leading cause of mortality and the most prevalent cancer worldwide. Most patients, who come with late-stage, have ineffective treatments and some side effects in chemotherapy.
Ariyanto, Eko Fuji, Bashari, Muhammad Hasan, Daffa, Dany Muhammad, Putri, Tenny, Qomarilla, Nurul   +4 more
core   +2 more sources

Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging – A scoping review

Biochemistry and Biophysics Reports
Prolonged ultraviolet (UV) exposure depletes the skin's endogenous antioxidants, leading to photoaging. Exogenous antioxidants are essential to counter this, with stilbenes such as pterostilbene and resveratrol emerging as promising candidates due to ...
Raveena Vaidheswary Muralitharan, Siti Fathiah Masre, Dayang Fredalina Basri, Ahmad Rohi Ghazali   +3 more
doaj   +1 more source

Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice

Antioxidants, 2021
To investigate the therapeutic effects of methanol extracts of Dipterocarpus tuberculatus Roxb. (MED) against UV-induced photoaging, we assessed for alterations in the antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances, and ...
Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, So Hae Park, Bounleuane Douangdeuane, Onevilay Souliya, Ju Min Park, Hee Seob Lee, Bae-Hwan Kim, Dae Youn Hwang   +10 more
doaj   +1 more source

A Novel Antioxidant Peptide Cath‐Np Derived from Nanorana parkeri Attenuates UVB‐Induced Skin Photodamage in Mice

Integrative Zoology, EarlyView.
Schematic representation of Cath‐Np as an antioxidant suppressing acute skin damage caused by ultraviolet B (UVB) radiation in mice. Cath‐Np inhibits the activation of p53 and mitogen‐activated protein kinase pathways while it activates the Nrf2 pathway by its strong antioxidant effects, and accordingly suppresses the expression of inflammatory factors
Hang Liao, Xiaoxiao Shen, Jinwei Chai, Kai wang, Jiena Wu, Jianxi Yang, Ming Chen, Guoxiang Mo, Xueqing Xu   +8 more
wiley   +1 more source

Oral Yak Whey Protein Can Alleviate UV-Induced Skin Photoaging and Modulate Gut Microbiota Composition

Foods
Excessive UV exposure can lead to skin roughness, wrinkles, pigmentation, and reduced elasticity, with severe cases potentially causing skin cancer. Nowadays, various anti-photoaging strategies have been developed to maintain skin health.
Diandian Wang, Yaxi Zhou, Jian Zhao, Chao Ren, Wenjie Yan   +4 more
doaj   +1 more source

Development of a high-throughput screening system for identification of novel reagents regulating DNA damage in human dermal fibroblasts [PDF]

, 2015
Ultraviolet (UV) radiation is a major inducer of skin aging and accumulated exposure to UV radiation increases DNA damage in skin cells, including dermal fibroblasts.
IN-SOOK AN, SEUNGHEE BAE, SUNGKWAN AN
core   +3 more sources

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Anti-Photoaging Effects ofAngelica acutilobaRoot Ethanol Extract in Human Dermal Fibroblasts

Toxicological Research, 2017
The effects that ultraviolet rays elicit on collagen synthesis and degradation are the most common causes of wrinkle formation and photo-aging in skin. The objectives of this study were to evaluate the effects of Angelica acutiloba root ethanol extract (AAEE) to promote collagen synthesis and inhibit collagen degradation in human dermal fibroblasts. By
Park, Min Ah, Sim, Mi Ja, Kim, Young Chul   +2 more
openaire   +3 more sources

Modified Qing’e Formula protects against UV-induced skin oxidative damage via the activation of Nrf2/ARE defensive pathway

Frontiers in Pharmacology, 2022
Exposure to ultraviolet (UV) light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, which increases oxidative stress damage and leads to photoaging.
Shan Zhu, Shan Zhu, Wenxiao Qin, Wenxiao Qin, Tao Liu, Tao Liu, Tao Liu, Tao Liu, Hongfei Ma, Hongfei Ma, Hongfei Ma, Cunyu Hu, Cunyu Hu, Xiaofeng Yue, Xiaofeng Yue, Yiqi Yan, Yiqi Yan, Yingshuang Lv, Yingshuang Lv, Zijing Wang, Zijing Wang, Zhiyue Zhao, Zhiyue Zhao, Zhiyue Zhao, Xiang Wang, Xiang Wang, Yan Liu, Qingmei Xia, Qingmei Xia, Han Zhang, Han Zhang, Nan Li, Nan Li, Nan Li   +33 more
doaj   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source