Results 71 to 80 of about 495 (136)

Stereoselective Skin Anti-photoaging Properties of Ginsenoside Rg3 in UV-B-Irradiated Keratinocytes

Biological and Pharmaceutical Bulletin, 2014
Ginsenosides are major bioactive constituents that are responsible for the diverse pharmacological activities of ginseng. This work aimed to assess the skin anti-photoaging activities of the two stereoisomeric forms of ginsenoside Rg3, 20(S)-Rg3 and 20(R)-Rg3. When the two Rg3 stereoisomers were added to cultured human keratinocyte HaCaT cells prior to
Lim, Chang-Jin, Choi, Woo-Yong, Jung, Hyun-Joo   +2 more
openaire   +3 more sources

Characterization, Identification, and Antioxidant Mechanism of Antioxidant Peptides From Schisandra chinensis Based on Peptidome and Molecular Docking/Dynamics

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Schisandra chinensis peptides (SCP) exhibited potent in vitro antioxidant activity and repaired UVB‐induced oxidative damage in HaCaT cells, while demonstrating excellent stability and biosafety. SCP also activated the Keap1/Nrf2 pathway, with IFSPWL identified as the key bioactive peptide that forms the most stable Keap1 complex via integrated ...
Shuo Zheng, Xingyu Xiao, Yi Li, Tong Su, Qinchuan Lv, Jiayuan Fang, Linlin Hao, Huayi Lu   +7 more
wiley   +1 more source

The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways

BMC Complementary and Alternative Medicine, 2018
Background Hesperidin is a flavonoid with antioxidant, anti-inflammatory, and immune modulatory activities. Photoaging is a consequence of chronic exposure to the sun and ultraviolet (UV) radiation.
Hee Jeong Lee, A-Rang Im, Su-Man Kim, Hyung-Sik Kang, Jae Dong Lee, Sungwook Chae   +5 more
doaj   +1 more source

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration

Aging Cell, Volume 25, Issue 6, June 2026.
Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu, Yuanyuan Lai, Chunhui Tian, Yufei Huang, Jianheng Hao, Yuemeng Zhao, Dan Chen, Tianyu Wu, Daqian Zhou, Xiaoyan Zheng, Han Yang, Zheng Yu, Nihong Li, Jie Yang   +13 more
wiley   +1 more source

Isovitexin attenuates oxidative stress-induced skin photoaging by suppressing cellular senescence: an insight provided by transcriptomic and metabolomic

Journal of Agriculture and Food Research
Aging skin has a disorganized barrier function, increasing the risk of diseases and malignant tumors. Isovitexin (Iso), a flavonoid with antioxidant, anti-cancer, neuroprotective, and lifespan-extending effects, may regulate skin photoaging, though its ...
Yanpei Gu, Qing Zhu, Yumei Qin, Jianzhong Han   +3 more
doaj   +1 more source

Beta‐Glucan: A Macrophage Differentiation Modulator That Accelerates the Wound Healing Response

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Beta Glucans (β‐glucans) are naturally occurring polysaccharides that have positive effects on healing in acute and chronic wounds. This study aimed to identify how β‐glucans modulate macrophage polarisation and inflammation to aid the healing response.
Stuart James Mills, Cyan Sylvester, Darryl Reed, Tony Charara, Allison June Cowin   +4 more
wiley   +1 more source

Skin Boosters: 2026 Updated

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Skin boosters are increasingly used to improve dermal quality through injectable and device‐assisted approaches; however, definitions and clinical evidence remain heterogeneous. Aims To provide an updated overview and propose a practical classification of skin boosters, including mechanisms, delivery methods, clinical outcomes, and limitations.
Kyu‐ho Yi, Hyunggyu Kang, Jong Keun Song, Olena Sydorchuk, Jeremy B. Green, Hugues Cartier, Roya Zarmehr Zamin, Benjamin Ascher   +7 more
wiley   +1 more source

Design and Synthesis of Hydroxamate-Based Matrix Metalloproteinase-2 Inhibitors for Anti-Photoaging

Journal of Microbiology and Biotechnology
Matrix metalloproteinases-2 (MMP-2) is crucial for collagen degradation at the dermal-epidermal junction, contributing to skin aging and photoaging. This study presents a series of hydroxamate-based inhibitors selectively targeting MMP-2. Through structure-activity relationship analysis, we systematically modified the N-arylsulfonyl group and amino ...
Lee, Jin Young, Jang, Geunhyuk, Joo, Yung Hyup, Choi, Joonho, Lee, Dong-Woo, Yoo, Jae Won   +5 more
openaire   +2 more sources

Liquid‐Form Polycaprolactone Injection Enhances Dermal Thickness and Collagen Production in UVB‐Induced Photoaging Skin

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Skin aging is driven by intrinsic and extrinsic factors, with ultraviolet (UV) radiation recognized as the primary cause of photoaging. Photoaged skin is characterized by reduced dermal thickness and collagen content. Recently, a liquid form of polycaprolactone (PCL) designed to promote uniform scaffold formation within the skin has
Jimyung Seo, Nouren Octresna, Chanjong Lee, Wonkyu Hong, Solam Lee, Meilinah Hidayat, Rudy Haryono, HyunSeok Kim, Teresa Liliana, Sang Ju Lee   +9 more
wiley   +1 more source

Antiphotoaging effects of a group of antioxidant peptides through downregulating matrix metalloproteinases and inflammation factors

Frontiers in Cell and Developmental Biology
Excessive ultraviolet B (UVB) exposure is the leading environmental contributor to the development of skin aging, also referred to as photoaging. We previously obtained a group of modified antioxidant peptides (WP5, LW5 and YY6), which were derived from ...
Yichao Huang, Juxingsi Song, Zhengbang Wang, Shaoqian Zhu, Yanan Hu, Xinyue Gan, Sai Luo, Qian He, Liming Zhang, Qianqian Wang   +9 more
doaj   +1 more source