Results 51 to 60 of about 129,223 (217)

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Atenção farmacêutica aos pacientes pediátricos portadores de infecção pelo HIV e seus cuidadores: Darlene Maria Stollmeier ; orientadora, Mareni Rocha Farias [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.Introdução: A síndrome da Imunodeficiência Adquirida (Aids), tem sido alvo de muitos estudos científicos em todo o mundo ...
Stollmeier, Darlene Maria
core  

Evaluation of the Impact of Anti-Retroviral Therapy on the Prevalence of Oral Lesions in Human Immunodeficiency Virus Infected Patients

پزشکی بالینی ابن سینا, 2013
Introduction & Objective: Oral lesions have important diagnostic and prognostic roles in HIV infected patients. It seems that HAART reduces the prevalence of oral lesions. The aim of the present study was to evaluate the prevalence of oral lesions in HIV
Poorandokht Davoodi, Hamidreza Abdolsamadi, Shabnam Seyedzadeh Saboonchi, Mina Jazaeri   +3 more
doaj  

[Study of interactions between anti-retroviral agents and concomitant drugs].

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2003
Clinical efficacy of antiretroviral treatment requires drugs to maintain a plasma concentration over MIC90. One of the facts that can prevent drugs from reaching and maintaining required concentrations are pharmacological drug interactions.The aim of this study is to identify the main interactions between antiretroviral medicines and concomitant ...
M A, Mur Lalaguna, R, Cobo Campos, M F T, Hurtado Gómez, M J, Martínez Tutor   +3 more
openaire   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Risk of severe bacterial infections including TB before and after immediate or deferred antiretroviral therapy: A multicenter, prospective, cohort study

International Journal of Infectious Diseases
Objectives: Deferring antiretroviral therapy (ART) until a CD4 count below cells/mm3 or other clinical indication in people with HIV (PWH) carries an increased risk of severe bacterial infections and tuberculosis (TB).
Tomas O. Jensen, Shweta Sharma, Anchalee Avihingsanon, Joseph Lutaakome, Indira Brar, William Burman, Ploenchan Chetchotisakd, Nathalie de Castro, Juan-Francisco Galán-Herrera, Nagalingeswaran Kumarasamy, Roger Paredes, Rene Ridzon, Michael Sciaudone, Kanal Singh, Alison Uriel, Jens Lundgren, Cavan Reilly, Gail Matthews   +17 more
doaj   +1 more source

A Tale of Two Conditions: 50 Years of Chronic Illness and Cancer From a Nursing Perspective

Journal of Advanced Nursing, EarlyView.
ABSTRACT Introduction In this commentary, I consider the disparity between the care we see as a necessity for cancer patients and the lack of care we afford to many persons with chronic disease. Background I ground my arguments in my own clinical practice and research experiences over a 50‐year period augmented by reference to available literature ...
Sally Thorne
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

A Combined Recombinant Retroviral-Based Therapy for Colon Cancer in the Murine Model Using Anti-Tumorigenic and Anti-Angiogenic Agents [PDF]

, 2011
Anti-tumorigenic gene therapy offers many benefits over than conventional therapy i.e., chemotherapy or radiotherapy including less toxic side effects, rapid delivery and more sensitive compared to target-based drugs.
Nik Abd. Rahman, Nik Mohd. Afizan
core  

Anti-Sharing. [PDF]

Anti-Sharing may solve the sharing problem of teams: the team members promise a fixed payment to the Anti-Sharer. He collects the actual output and pays out its value to them. We prove that the internal Anti- Sharer is unproductive in equilibrium.
Roland Kirstein, Robert Cooter
core   +3 more sources