Results 81 to 90 of about 70,195 (211)

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Lamivudine’s efficacy and safety in preventing mother-to-child transmission of hepatitis B: A meta-analysis

The Turkish Journal of Gastroenterology, 2019
Background/Aims: Mother-to-child transmission (MTCT) is a common transmission mode of hepatitis B virus (HBV). It has been shown that the infection may occur in some infants despite the use of immunoprophylaxis, and many studies have demonstrated the ...
Pooyan Khalighinejad, Seyed Moayed Alavian, Mohammad Gholami Fesharaki, Rozita Jalilianhasanpour   +3 more
doaj   +1 more source

Remembering the forgotten child: the role of immune checkpoint inhibition in patients with human immunod eficiency virus and cancer. [PDF]

, 2019
Patients with human immunodeficiency virus (HIV) infection have a high risk of developing virally-mediated cancers. These tumors have several features that could make them vulnerable to immune checkpoint inhibitors (ICIs) including, but not limited to ...
Adashek, Jacob J, Galanina, Natalie, Junior, Pedro Nazareth Aguiar, Kurzrock, Razelle   +3 more
core  

Hierarchical Citizenship and Racialised Discretion: Police and Consular Officers’ Handling of Capital Cases in Malaysia

The Howard Journal of Crime and Justice, EarlyView.
ABSTRACT This article examines the death penalty in Malaysia, where foreign nationals have historically been sentenced to death at a disproportionately high rate. The international community has recognised that foreign defendants are disadvantaged in alien criminal justice systems and made efforts to address this through the United Nation's Vienna ...
Carolyn Hoyle, Lucy Harry
wiley   +1 more source

Início da terapia anti-retroviral em estágio avançado de imunodeficiência entre indivíduos portadores de HIV/AIDS em Belo Horizonte, Minas Gerais, Brasil Initiation of antiretroviral therapy in HIV-infected patients with severe immunodeficiency in Belo Horizonte, Minas Gerais State, Brazil

Cadernos de Saúde Pública, 2009
O objetivo deste trabalho foi verificar a proporção de início tardio da terapia anti-retroviral (TARV) e seus fatores associados. Estudo de corte transversal com pacientes de dois serviços públicos de referência (n = 310) em Belo Horizonte, Minas Gerais,
José Roberto Maggi Fernandes, Francisco de Assis Acurcio, Lorenza Nogueira Campos, Mark Drew Crosland Guimarães   +3 more
doaj   +1 more source

The Double Burden. [PDF]

, 2013
One third of the world's population is latently infected with Mycobacterium tuberculosis, and with the lifestyle changes succeeding the on-going urbanization, populations already burdened by tuberculosis are experiencing a dramatic increase in chronic ...
Faurholt-Jepsen, Daniel
core  

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source

Generation of Transgenic Mice to Evaluate Promoter Activity and Specificity of Two Human Endogenous Retrovirus Long Terminal Repeats = Untersuchungen zur Promotor-Aktivität und -Spezifität von zwei Long Terminal Repeats humaner endogener Retroviren in transgenen Mäusen [PDF]

, 2003
Generation of Transgenic Mice to Evaluate Promoter Activity and Specificity of two Human Endogenous Retrovirus Long Terminal Repeats Human Endogenous Retrovirus Long Terminal Repeats (HERV-LTRs) comprise 1.8% of the human genome (52.7 Mb).
Schönfeld, Regine Margarete
core  

Variation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approach [PDF]

, 2015
BACKGROUND Recent trends to earlier access to anti-retroviral treatment underline the importance of accurate HIV diagnosis. The WHO HIV testing strategy recommends the use of two or three rapid diagnostic tests (RDTs) combined in an algorithm and assume ...
Glass, Kathryn, Klarkowski, Derryck, Lokuge, Kamalini, O’Brien, Daniel, Piriou, Erwan, Shanks, Leslie   +5 more
core   +1 more source

A Tale of Two Conditions: 50 Years of Chronic Illness and Cancer From a Nursing Perspective

Journal of Advanced Nursing, EarlyView.
ABSTRACT Introduction In this commentary, I consider the disparity between the care we see as a necessity for cancer patients and the lack of care we afford to many persons with chronic disease. Background I ground my arguments in my own clinical practice and research experiences over a 50‐year period augmented by reference to available literature ...
Sally Thorne
wiley   +1 more source