Results 81 to 90 of about 129,223 (217)

Human immunodeficiency virus infection and autoimmune hepatitis during highly active anti-retroviral treatment: a case report and review of the literature

Journal of Medical Case Reports, 2011
Introduction The emergence of hepatic injury in patients with human immunodeficiency virus infection during highly active therapy presents a diagnostic dilemma. It may represent treatment side effects or autoimmune disorders, such as autoimmune hepatitis,
Higgins Martha, Kamran Farah, Nasser Haitham, Khatib Riad, Daas Hanady, Saravolatz Louis   +5 more
doaj   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

New Anti-Telomerase Anti-Cancer Agents

, 2008
The unlimited proliferative potential of cancer cells depends on telomere maintenance. Optimal telomerase activity requires in chromosomal DNA an unfolded single-stranded telomeric overhang.
PETRACCONE, LUIGI
core  

Out-of-pocket Expenditure and its Impact on the Quality of Life among Patients Attending the Anti-retroviral Therapy Centre of a Tertiary Care Hospital in Kolkata [PDF]

Healthline
Introduction: Out-of-pocket expenditure (OOPE) has a negative impact on Quality of life (QoL) of People Living with HIV (PLHIV)which can increase the risk of slipping into poverty. Objectives: Primary Objective of this study was to estimate the burden of
Mamunur Rashid, Dipendra Narayan Goswami, Kuntala Ray, Mausumi Basu, Aparajita Mondal, Abhipsa Dey   +5 more
doaj   +1 more source

HIV-1 integrase resistance in the context of antiretroviral therapy in paediatric patients ‒ Northeast Brazil

Brazilian Journal of Infectious Diseases
Introduction: Antiretroviral drug resistance poses a challenge to therapy efficacy. Although Integrase Strand Transfer Inhibitors (INSTIs) have a high genetic barrier to resistance, few studies in Brazil have focused on INSTI resistance. This study aimed
Aldicléya Lima Luz, Élcio Leal, Kledoaldo Lima, Mikhael Morais de Souza, Michelle Lima de Carvalho Silva, Mayra Moura Lima, Paloma Gomes Tavares Sette, Yasmim Leandra Moura de Almeida, Heloísa Ramos Lacerda de Melo   +8 more
doaj   +1 more source

Anti-Cancer Agents in Medicinal Chemistry

, 2013
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
CAPRANICO, GIOVANNI
core  

Glucuronides in anti-cancer therapy

, 2003
Glucuronide prodrugs have shown promising efficacy in anti-cancer therapy due to their increased specificity and reduced systemic toxicity. The prodrugs can be used in prodrug monotherapy (PMT), which is based on elevated tumor beta-glucuronidase ...
Wu, Bingyuan, Chen, Xi, Wang, Peng George   +2 more
core   +1 more source

Withdrawal Notice: Recent Developments in Anti-Cancer Activity of Compounds Containing the Thioether Group

, 2020
The article has been withdrawn by the Editorial office of the journal Anti-Cancer Agents in Medicinal Chemistry because of the lack of clarity and obscurity in the content regarding language.

core   +1 more source

Prevalence of acquired and transmitted HIV drug resistance in Iran: a systematic review and meta-analysis

BMC Infectious Diseases
Background There is no systematic review on the prevalence of HIV drug resistance (HIVDR) in Iran. We aimed to estimate the prevalence of HIVDR among people living with HIV (PLHIV) in Iran.
Hossein Mirzaei, Sana Eybpoosh, Fatemeh Mehrabi, Mohammad Reza Shojaei, Ali Mirzazadeh, Mehrdad Khezri, Naser Nasiri, Hamid Sharifi   +7 more
doaj   +1 more source

Tumour‐Derived Extracellular Vesicles Induce Diffuse Large B‐Cell Lymphoma Progression Through Macrophage‐Mediated MDSC Accumulation

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Elevated peripheral myeloid‐derived suppressor cells (MDSCs) predicted suppressed anti‐tumour immunity and poor prognosis in diffuse large B‐cell lymphoma (DLBCL) patients. Here we demonstrated that tumour‐derived extracellular vesicles (EVs) served as a messenger, delivering cholesterol from lymphoma cells to macrophages.
Mengke Liu, YingYu Dong, Qixiao Guan, JianBiao Wang, Qing Shi, RongGui Lin, Muchen Zhang, Di Fu, Shu Cheng, Pengpeng Xu, Eurydice Angeli, Guilhem Bousquet, Wenguo Cui, Hongjing Dou, Wei‐Li Zhao, Li Wang   +15 more
wiley   +1 more source