Results 111 to 120 of about 49,611 (279)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Seizure control in patients with epilepsy: the physician vs. medication factors [PDF]

, 2008
Background Little is known about the relationship between types of healthcare providers and outcomes in patients with epilepsy. This study compares the relative effects of provider type (epileptologist vs.
Magdalena Szaflarski, Lindsell Christopher J, Angela Y Rackley, Szaflarski Magdalena, Rackley Angela Y, Szaflarski Jerzy P, Christopher J Lindsell, Jerzy P Szaflarski, Yates Stephen L, Stephen L Yates   +9 more
core   +1 more source

Comparative effectiveness of anti-seizure medications in emulated trials using medical informatics

Brain
Abstract Anti-seizure medications (ASMs) are often prescribed using a trial-and-error approach with a similar sequence for many patients. Comparative effectiveness data beyond the first ASM prescription are limited. Artificial intelligence can automatically extract information from electronic health records (EHRs) and augment clinical
Kevin Xie, Jacob Korzun, Daniel J Zhou, Ellie Chang, Nina J Ghosn, Sarah Lavelle, Arman Oganisian, Emily K Acton, Michael A Gelfand, Dan Roth, Brian Litt, Colin A Ellis   +11 more
openaire   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Alternative psychosis (forced normalisation) in epilepsy

South African Journal of Psychiatry, 2011
Forced normalization is a paradoxical relationship between seizure activity and behavioural problems. A 20 year old male with recurrent refractory tonic clonic epilepsy experienced forced normalization, whilst on medication with multiple anti- epileptic ...
Vongani Titi Raymond Ntsanwisi, Solomon T Rataemane, Dali S Magazi   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Adherence to anti-hypertensive medication: Proposing and testing a conceptual model

, 2011
Objectives. A conceptual model of the psychological factors underpinning adherence to anti-hypertensive medication is proposed and tested. The model suggests that adherence is influenced by three sets of variables: demography, health status, and ...
Derek R. Rutter, Rutter, D., Susan Thompson, Quine, L., Thompson, S., Rutter, D. R., Liz Steadman, Lyn Quine, Steadman, L.   +8 more
core   +1 more source

Neuropsychiatric comorbidities in adult patients with new-onset epilepsy

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Neuropsychiatric comorbidities in adult patients with new-onset epilepsy in our university hospitals has not been assessed, so the purpose of this study was to identify the neuropsychiatric comorbidities in adult patients with new onset ...
Rania S. Nageeb, Adham Mahmoud Mohamad Ismail, Sawsan Abd El Aziz Youssef, Eman Atef Mohamed   +3 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Comparative effectiveness of epilepsy surgery versus additional anti-seizure medications for Lennox–Gastaut syndrome: study protocol for a multicenter, mixed-methods study

Frontiers in Neurology
IntroductionLennox–Gastaut Syndrome (LGS) is a severe developmental epileptic encephalopathy without a known cure. Management of symptoms requires substantial care. Treatment options include anti-seizure medications, dietary therapy, and epilepsy surgery.
Sandi Lam, Sandi Lam, Marc Rosenman, Marc Rosenman, Tracy Dixon-Salazar, Kelly G. Knupp, Liu Lin Thio, Taylor J. Abel, Taylor J. Abel, William P. Welch, William P. Welch, Laurel Reed, Laurel Reed, Stephanie C. Randle, Stephanie C. Randle, Rebecca Garcia-Sosa, Rebecca Garcia-Sosa, Jason S. Hauptman, Carolyn C. Foster, Carolyn C. Foster, Elizabeth R. Alpern, Elizabeth R. Alpern, Lu Zhang, Lu Zhang, Nicole Villalba, Nicole Villalba, Maura Carroll, Anup D. Patel   +27 more
doaj   +1 more source