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Starting a new anti‐seizure medication in drug‐resistant epilepsy: Add‐on or substitute?

Epilepsia, 2021
Objectives: Randomized studies in drug-resistant epilepsy (DRE) typically involve addition of a new anti-seizure medication (ASM). However, in clinical practice, if the patient is already taking multiple ASMs, then substitution of one of the current ASMs
Mubeen Janmohamed, Katrina Spilsbury, John Dunne   +2 more
exaly   +2 more sources

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The effect of anti-seizure medications on lipid values in adults with epilepsy

Epilepsy & Behavior, 2023
Certain anti-seizure medications (ASMs) adversely impact lipid values. Here, we explored the impact of ASMs on lipid values in adults with epilepsy.A total of 228 adults with epilepsy were divided into four groups based on ASMs used: strong EIASMs, weak EIASMs, non-EIASMs, and no ASMs.
Ashley L. Muller, Luisa Diaz-Arias, Mackenzie C. Cervenka, Tanya J.W. McDonald   +3 more
openaire   +2 more sources

Anti-seizure Medications: Challenges and Opportunities

CNS & Neurological Disorders - Drug Targets
Abstract: Epilepsy is a chronic neurological condition characterized by unprovoked, recurrent seizures. There are several types of epilepsy, and the cause of the condition can vary. Some cases of epilepsy have a genetic component, while others may be caused by brain injuries, infections, or other underlying conditions. Treatment for epilepsy typically
Neha Tandon, Milica Radosavljevic, Danijela Vucevic, Miroslav Radenkovic, Jasna Jancic, Janko Samardzic   +5 more
openaire   +2 more sources

Seizure exacerbation with anti-seizure medications in adult patients with epilepsy

Epilepsy Research, 2022
There are numerous reports of seizure exacerbation related to specific anti-seizure medications (ASMs); however, a quantitative analysis with clearly defined parameters for seizure exacerbation in an outpatient setting is lacking. This retrospective study examines adult patients starting a single ASM and follows patient outcomes over the course of ...
Maria A, Jaramillo, Timothy, Pham, Sohail, Kamrudin, Rahul, Khanna, Atul, Maheshwari   +4 more
openaire   +2 more sources

Pricing dynamics of anti-seizure medications in the U.S.

Seizure: European Journal of Epilepsy
The median cost of anti-seizure medications (ASM) in the United States (U.S.) nearly doubled per person between 2006 and 2021. This increase, combined with shifts in ASM usage and the impact of the COVID-19 pandemic on drug supply chains amid rising inflation, underscored the urgent need to scrutinize ASM pricing dynamics.
Pradeep Javarayee, Tengizi Mtchedlidze, Wanda Snell, Vibha Mahesha, Jennifer Meylor, Shamshad Shahrukh, Shannon Pollock, Jeetendra Sah, Yilu Dong, Hema Patel   +9 more
openaire   +2 more sources

Anti-Seizure Medications and Estradiol for Neuroprotection in Epilepsy: The 2013 Update

Recent Patents on CNS Drug Discovery, 2013
Current epilepsy therapy is still symptomatic using anti-seizure, rather than anti-epileptic, medications. This therapy may control the seizure activity but does not prevent or even cure epilepsy. Treatment strategies that could interfere with the process leading to epilepsy (epileptogenesis) would have significant benefits over the current approaches.
Libor, Velisek, Nino, Nebieridze, Tamar, Chachua, Jana, Veliskova   +3 more
openaire   +2 more sources

Scalp EEG Correlates of Anti-Seizure Medications in Adult Epilepsy

2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
An anti-seizure medication (ASM) regimen that relieves seizure burden for patients with epilepsy can take weeks to months to establish or become ineffective over time and require revision. There is no clear clinical algorithm for choosing one specific ASM regimen over another, and an ASM is often chosen based on a patient's individual characteristics ...
Alana Chandler, Amir Hossein Daraie, Patrick Myers, Jeff Craley, Sridevi Sarma, Joon-Yi Kang   +5 more
openaire   +2 more sources

Differential Effects of Anti-Seizure Medications on Sarcopenia in Patients With Epilepsy

Clinical Therapeutics
Epilepsy is a chronic neurological disorder that often requires long-term use of anti-seizure medications (ASMs). While ASMs are known to affect bone health, their impact on muscle mass and the development of sarcopenia has not been well studied. This study investigated the association between ASM use and sarcopenia in patients with epilepsy and ...
Yu-Shiue Chen, Ming-Chi Lai, Huai-Chun Huang, Huai-Ying Ingrid Huang, Chin-Wei Huang   +4 more
openaire   +2 more sources

Adequate and inadequate dosing of anti-seizure medications in status epilepticus

Epilepsy Research
Status epilepticus (SE) is defined as five or more minutes of continuous seizures or two or more discrete seizures with incomplete recovery of consciousness.1 The incidence of SE in the United States ranges from 18.3 to 41 per 100,000 patients per year2.
Susan Schrader, Melissa Smith
openaire   +2 more sources

Pattern of anti-seizure medications and predictors of depression in people with epilepsy

Neurological Research
This cross-sectional study recruited 940 PWE attending outpatient clinics of selected tertiary hospitals in southwestern Nigeria, with diagnosis confirmed clinically and supported by electroencephalography (EEG), aged ≥15 years, with no history of psychogenic non-epileptic seizures.
Ogunjimi Luqman, Ogunjimi Olabisi, Alabi Akinyinka, Aderinola Aderonke, Murtala Akanji, Oyenuga Ibironke, Kasumu Emmanuel, Alli Khadijat, Fagbemi Ayotomiwa, Akindolani Precious, Akinbodu Shittabey, Ottun Kofoworola, Adeyemo Stella, Johnson Deborah, Oluseyije Oluwatobiloba, Kasali Adeola, Osalusi Bamidele, Fehintola Fatai   +17 more
openaire   +2 more sources