Results 41 to 50 of about 46,192 (239)

Anti-Seizure Medications and Estradiol for Neuroprotection in Epilepsy: The 2013 Update

, 2013
Current epilepsy therapy is still symptomatic using anti-seizure, rather than anti-epileptic, medications. This therapy may control the seizure activity but does not prevent or even cure epilepsy.
Nebieridze, Nino, Chachua, Tamar, Veliskova, Jana, Velisek, Libor   +3 more
core   +1 more source

Poor Seizure Control Among Children Attending a Tertiary Hospital in South Western Uganda – A Retrospective Study

International Journal of General Medicine, 2023
Jane Namusisi,1,2 Stella Kyoyagala,1 Josephine Nantongo,2 Mike Kyewalyanga,1,3 Stephen Sabiiti,1 Angelique Murorunkwere,1 Josephine Nambi Najjuma,1 Jane Nakibuuka,4 Mark Kaddumukasa,4 Martha Sajatovic,5 Peter Kalubi1 1Department of Pediatrics and Child ...
Namusisi J, Kyoyagala S, Nantongo J, Kyewalyanga M, Sabiiti S, Murorunkwere A, Najjuma JN, Nakibuuka J, Kaddumukasa M, Sajatovic M, Kalubi P   +10 more
doaj  

Molecular and genetic mechanisms of neurotoxicity during anti-seizure medications use

Revista de Investigación Clínica, 2023
Epilepsy is a multifactorial pathology that has allowed the development of various drugs aiming to combat it. This effort was formally initiated in the 1940s when phenytoin began to be used. It eventually turned out to be a drug with great anticonvulsant
Carmen Rubio, Fernando Gatica, Eric Uribe, Ernesto Ochoa, Victoria Campos, Moisés Rubio-Osornio   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Measurement of levetiracetam drug levels to assist with seizure control and monitoring of drug interactions with other anti-epileptic medications (AEMs)

, 2014
PurposeLevetiracetam (LEV) therapeutic range (20–40mg/L) and potential drug interactions were assessed in people with epilepsy (PWE).MethodFifty-two PWE had LEV and concomitant medications [carbamazepine (CBZ); valproate (VPA); lamotrigine (LTG)] blood ...
Stepanova, Daria, Beran, Roy G., Beran, Roy G, Beran, Roy   +3 more
core   +1 more source

Hot Water Epilepsy in Children: A Rare Form of Reflex Epilepsy

Journal of Pediatric Research
Aim: We evaluated the clinical and electroencephalography (EEG) characteristics, treatments, and outcomes of children with hot-water epilepsy (HWE), a specific type of reflex epilepsy. Materials and Methods: This retrospective study included 11 children
Ayfer Arduç Akçay, Serap Uysal
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Seizure cluster: Definition, prevalence, consequences, and management

, 2019
•Seizure clusters are common in patients with refractory epilepsy.•There is no agreed upon definition for seizure clusters.•Rescue medications are underutilized in seizure clusters.•Non-rectal, non-IV benzodiazepines are safe and effective in the ...
Saba Jafarpour, Kellinghaus, Christoph, Hirsch, Lawrence J, Marina Gaínza-Lein, Lawrence J. Hirsch, Jafarpour, Saba, Gaínza-Lein, Marina, Christoph Kellinghaus, Detyniecki, Kamil, Kamil Detyniecki   +9 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Experience with the ketogenic diet in premature neonates

Epilepsia Open, 2023
The ketogenic diet is a time‐tested, potent, nonpharmacological treatment of epilepsy. However, the use of the ketogenic diet in premature neonates with epilepsy has not been previously reported.
Chalongchai Phitsanuwong, Jeong‐A Kim, Stephanie Schimpf, Douglas R. Nordli Jr   +3 more
doaj   +1 more source