Results 51 to 60 of about 46,192 (239)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Quality of Life in People with Epilepsy: The Associations of Anti-seizure Medications and Biopsychosocial Variables

, 2022
People with epilepsy, on average, experience lower quality of life (QOL) than healthy controls (Taylor et al., 2011). This study examined the associations between specific anti-seizure medication, biopsychosocial factors, and QOL in people with epilepsy.
Thomas, Julia A.
core  

Characteristics of an advanced epilepsy treatment gap in a region in Japan

Epilepsy & Behavior Reports, 2023
To investigate the quality of epilepsy care in a region in Japan that lacked specialised care, we retrospectively evaluated patients who visited our newly established epilepsy division between April 2018 and March 2021, and had been treated with anti ...
Tetsuhiro Fukuyama, Manami Yabe, Makoto Nishioka, Takenori Natsume, Yuumi Hoshino, Kohei Kanaya, Kyoko Takano, Norimoto Kobayashi, Yushi Inoue   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exposure to anti-seizure medications impact growth of gut bacterial species and subsequent host response

, 2022
International audienceAnti-seizure medications (ASMs) are the first line of treatment for seizure control in children with epilepsy. Cumulative evidence suggests an imbalanced gut microbiota in refractory epilepsy patients. We systematically investigated
Lapaque, Nicolas, Brochard, Vincent, Ilhan, Zehra Esra, Auvin, Stéphane, Lepage, Patricia   +4 more
core   +1 more source

Acute symptomatic seizure: structural brain lesions, metabolic disorders, anti-seizure medications

Медицина неотложных состояний
Seizures that occur in close temporal relation to brain lesions and do not recur after resolution of the pathological condition or elimination of the factor that caused it should be considered as acute symptomatic seizures.
A.Ye. Dubenko, L.B. Maryenko, T.A. Litovchenko, A.V. Litovchenko, K.M. Maryenko, H.I. Seliukov   +5 more
doaj   +1 more source

Experimental Therapeutic Strategies in Epilepsies Using Anti-Seizure Medications

Journal of Experimental Pharmacology, 2021
Fakher Rahim,1 Reza Azizimalamiri,2 Mehdi Sayyah,3 Alireza Malayeri4,5 1Molecular Medicine and Bioinformatics, Research Center of Thalassemia & Hemoglobinopathy, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;
Rahim F, Azizimalamiri R, Sayyah M, Malayeri A   +3 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Effect of Anti-seizure Medications on the Propagation of Epileptic Activity: A Review

Frontiers in Neurology, 2021
The propagation of epileptiform events is a highly interesting phenomenon from the pathophysiological point of view, as it involves several mechanisms of recruitment of neural networks.
Mohamed Khateb, Noam Bosak, Moshe Herskovitz, Moshe Herskovitz   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source