Results 61 to 70 of about 13,208 (153)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Two new Anti-TMV active chalconoid analogues from the root of Phyllanthus emblica

Natural Product Research, 2017
Two new chalconoid analogues, emblirol A (1) and B (2), along with three known ones (3–5), were isolated from the root of the Phyllanthus emblica L. Their structures were elucidated on the basis of spectral data. Compound 1 and 2 showed moderate anti-TMV activity with inhibition rates 79.6 and 62.1% at a concentration of 1 mg/mL, respectively.
He, Yan, Li Rong, Han, Xing, Zhang, Jun Tao, Feng   +3 more
openaire   +2 more sources

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, Volume 13, Issue 30, 28 May 2026.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Virus‐Induced Gene Silencing in Calendula officinalis (Pot Marigold)

Plant Direct, Volume 10, Issue 5, May 2026.
ABSTRACT Virus‐induced gene silencing (VIGS) is a method that exploits plant antiviral defense mechanisms to downregulate endogenous genes. The technique is versatile, rapid, and widely used for functional genomics studies. Here, we report a method for VIGS in the medicinal plant, Calendula officinalis (pot marigold).
Daria Cuthbert, Connor Tansley, Melissa Salmon, Nicola Patron   +3 more
wiley   +1 more source

The Use of Bacteria, Actinomycetes and Fungi in the Bioprotection of Solanaceous Crops against Tobacco Mosaic Virus (TMV)

Agriculture
Tobacco mosaic virus (TMV) is one of the most persistent and infectious plant viruses. The substantial economic losses caused by TMV in the production of tobacco and vegetables (especially in the Solanaceae family) are prompting the introduction of ...
Anna Trojak-Goluch
doaj   +1 more source

Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi

Marine Drugs, 2018
Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry.
Pengbin Guo, Gang Li, Yuxiu Liu, Aidang Lu, Ziwen Wang, Qingmin Wang   +5 more
doaj   +1 more source

Targeting ParPMC Susceptibility Hubs in Prunus: eEF1A as a Conserved Mediator of Plum Pox Virus Infection in Nicotiana benthamiana

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
ParPMC interactors were screened, highlighting eEF1A proteins; co‐localization and VIGS show their role in PPV infection and sharka susceptibility. ABSTRACT Sharka, caused by Potyvirus plumpoxi (plum pox virus, PPV), is the most destructive viral disease affecting Prunus species worldwide.
Ángela Polo‐Oltra, Alba Lloret, Jesús A. Sánchez‐Navarro, Gabino Ríos, Carlos Romero, Elena Zuriaga   +5 more
wiley   +1 more source

Anti-TMV Effects of Amaryllidaceae Alkaloids Isolated from the Bulbs of Lycoris radiata and Lycoricidine Derivatives

Natural Products and Bioprospecting, 2018
Fifteen known amaryllidaceae alkaloids were isolated from the bulbs of Lycoris radiata. Some of the compounds and lycoricidine derivatives had been screened for the activities against tobacco mosaic virus (TMV) by the conventional half-leaf method ...
Dong-Qiong Yang, Zhao-Rong Chen, Duo-Zhi Chen, Xiao-Jiang Hao, Shun-Lin Li   +4 more
doaj   +1 more source

Cucumber Mosaic Virus Coat Protein Sequesters Host CDPK7‐Like Into Phase‐Separated Condensates to Promote Viral Infection

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
This study reveals a tripartite pesticide–pathogen–host interaction in which the host kinase CDPK7‐like in Nicotiana benthamiana interacts with cucumber mosaic virus coat protein (CMV CP) to form LLPS‐driven condensates that facilitate viral infection.
Lei Zhao, Tangbing Yang, Xingjie Zhang, Chunni Zhao, Qingwei Song, Deyu Hu, Lu Yu, Runjiang Song   +7 more
wiley   +1 more source