Results 111 to 120 of about 2,675,396 (301)

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease

, 2017
Hitoshi Amano,1 Reikei Matsuda,1 Tomohiko Shibata,2 Daisuke Takahashi,1 Shinichiro Suzuki3 1Department of Gastroenterology, Fujisawa Shonandai Hospital, Fujisawa, 2Division of Rheumatology, Department of Internal Medicine, St Marianna University School ...
Amano H, Takahashi D, Suzuki S, Shibata T, Matsuda R   +4 more
core  

Quantitative comparison of the neutralizing capacity, immunogenicity and cross-reactivity of anti-TNF-α biologicals and an Infliximab-biosimilar.

PLoS ONE, 2018
IntroductionTNF-α-neutralizing antibodies, such as infliximab (IFX) and adalimumab (ADA), are effective in the treatment of inflammatory bowel diseases (IBD), but they are expensive and become ineffective when patients develop anti-IFX or anti-ADA ...
D J Buurman, T Blokzijl, E A M Festen, B T Pham, K N Faber, E Brouwer, G Dijkstra   +6 more
doaj   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Effect of anti-IFN-γ + anti-TNF-α antibody on cytokine production in splenic aspirate cultures of human VL.

, 2018
Splenic supernatants from anti-IFN-γ + anti-TNF-α antibody treated cultures were used for estimation of cytokines employing ELISA. Value shown (A) IL-4 (pg/ml) and (B) IL-10 (pg/ml) are cytokine concentrations.
Neetu Singh (317211), Shyam Sundar (58354)   +1 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

, 2023
Background: Anti-TNF drugs are effective treatments for the management of Crohn's disease but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment ...
S Lin (3326841), A T Cole (13556383), A V J Gunasekera (13556371), P Dunckley (13556404), V Patel (7804106), P M Irving (13428747), T Mahmood (7810361), S Sonwalkar (13556410), N A Kennedy (13556275), M H Perry (13556290), D R Gaya (13556299), C U Nwokolo (13556380), P J R Banim (13556407), R Nice (13556287), H Jafferbhoy (13556425), A Willmott (13556431), J E Mawdsley (13556455), P Hendy (13556296), C P Selinger (13556305), C Mowat (7776473), S Sebastian (12221999), J S De Caestecker (13556428), A Thomas (841916), J Lindsay (13386681), A Butt (6886730), C Bell (13305693), Neel Heerasing (13087041), S Bouri (12222098), N Chanchlani (13556293), A Shenoy (13556377), T Orchard (13556467), S Murugesan (13556344), G Chung-Faye (100786), M Parkes (7655123), D Basude (13556350), M Harbord (13556449), A Hart (3561902), R Miller (7753373), C Tzivinikos (13556437), S de Silva (10002803), S Weaver (7629431), C Lees (13556395), J C Mansfield (13556314), B Hope (13556452), S L Bloom (13556440), C E MacDonald (13556368), J De La Revella Negro (13556365), V Kaushik (13556341), C W Lees (13556308), B Hamilton (11794709), C Bewshea (5785718), T H Iqbal (13556338), H Matthews (13433232), J O Lindsay (13474126), P S Babu (13556434), G A Heap (13556278), V Zamvar (12146040), L Gervais (13556401), S Singh (36962), J M Fell (13556446), N M Croft (13556443), A Agrawal (7723772), R Shenderey (13556419), J R F Cummings (13556302), R Hariraj (13556422), D Elphick (13556374), S Bridger (13556386), A Beale (13556353), B Colleypriest (13556332), D Ghosh (7940741), A Dhar (12222170), P Mayhead (13556392), D McGovern (13556320), L Armstrong (9149234), F Torrente (13556362), A L Hart (13556311), G J Walker (13556284), T J McDonald (13537906), S M Evans (13367403), G Jones (2555320), J Doherty (7709057), J R Goodhand (13556323), N Direkze (13556359), A Thakur (9895997), J W Hart (13556398), R H Phillips (13556413), R K Russell (13556317), H D Green (13556281), S Langlands (13556356), Z Mazhar (13556326), S C Cooper (13556389), T C Tham (13556335), C D Murray (13556464), A McNair (13556458), M Smith (7716890), R Saich (13556329), C Preston (13556347), A Azaz (13556416), K J Monahan (13556461), T Ahmad (5785727)   +99 more
core  

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Protein dysregulation during Leishmania infantum infection in anti-TNF immunosuppressed mice revealed through quantitative proteomics analysis of extracellular vesicles

Frontiers in Immunology
IntroductionVisceral leishmaniasis (VL) occurs more frequently in immunosuppressed individuals, especially those undergoing immunosuppressive drug therapy for an autoimmune disease.
Lorena Bernardo, Lorena Bernardo, Ana Montero-Calle, Jose Carlos Solana, Jose Carlos Solana, Marina Lozano-Rendal, Ana Torres, Ana Torres, Carmen Sánchez, Rodrigo Barderas, Rodrigo Barderas, Javier Moreno, Javier Moreno, Eugenia Carrillo, Eugenia Carrillo   +14 more
doaj   +1 more source

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

Advanced Materials, EarlyView.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song, Melissa Cadena, Myeongsoo Kim, Euisuk Chung, Jeungyoon Lee, Zlata Brushevich, Seonghun Shin, Paul S. Pelkowski, Stanislav Y. Emelianov   +8 more
wiley   +1 more source