Results 141 to 150 of about 4,564,900 (257)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

, 2019
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort ...
JC Mansfield (7655168), S Lin (3326841), P Dunckley (13556404), V Patel (7804106), T Mahmood (7810361), S Sonwalkar (13556410), MH Perry (15786794), NM Croft (15786839), DR Gaya (15786758), KJ Monahan (15786848), SL Bloom (15786836), JO Lindsay (14451168), R Nice (13556287), PS Babu (15786833), H Jafferbhoy (13556425), A Willmott (13556431), P Hendy (13556296), C Mowat (7776473), JS De Caestecker (15786830), S Sebastian (12221999), A Thomas (841916), J Lindsay (13386681), A Butt (6886730), C Bell (13305693), Neel Heerasing (13087041), CD Murray (15786851), S Bouri (12222098), CP Selinger (15786800), AT Cole (15786746), N Chanchlani (13556293), A Shenoy (13556377), TC Tham (15786806), T Orchard (13556467), S Murugesan (13556344), G Chung-Faye (100786), M Parkes (7655123), D Basude (13556350), M Harbord (13556449), A Hart (3561902), AVJ Gunasekera (15786815), R Miller (7753373), C Tzivinikos (13556437), GA Heap (15786737), S de Silva (10002803), TH Iqbal (15786809), S Weaver (7629431), JRF Cummings (15786797), C Lees (13556395), B Hope (13556452), J De La Revella Negro (13556365), V Kaushik (13556341), CU Nwokolo (15786818), B Hamilton (11794709), C Bewshea (5785718), GJ Walker (12222002), JR Goodhand (15786776), H Matthews (13433232), V Zamvar (12146040), L Gervais (13556401), S Singh (36962), RH Phillips (15786827), JW Hart (15786821), CE MacDonald (15786812), TJ McDonald (15786803), A Agrawal (7723772), R Shenderey (13556419), PJR Banim (15786824), R Hariraj (13556422), D Elphick (13556374), S Bridger (13556386), A Beale (13556353), NA Kennedy (12222005), B Colleypriest (13556332), D Ghosh (7940741), A Dhar (12222170), PM Irving (11289144), JM Fell (15786842), P Mayhead (13556392), AL Hart (15786761), RK Russell (7776491), D McGovern (13556320), CW Lees (7655129), L Armstrong (9149234), F Torrente (13556362), G Jones (2555320), J Doherty (7709057), N Direkze (13556359), A Thakur (9895997), S Langlands (13556356), Z Mazhar (13556326), JE Mawdsley (15786845), HD Green (15786791), SM Evans (14530529), A McNair (13556458), M Smith (7716890), SC Cooper (9947417), R Saich (13556329), C Preston (13556347), A Azaz (13556416), T Ahmad (5785727)   +99 more
core  

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Optimizing anti-TNF therapy in Behçet's disease: the role of therapeutic drug monitoring. [PDF]

Front Immunol
Barešić M, Smiljanić Tomičević L, Kozmar A, Mayer M.   +3 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Anti-TNF therapy attenuates the diagnostic utility of leucine-rich α2-Glycoprotein 1 for endoscopic activity in ulcerative colitis. [PDF]

Ther Adv Gastroenterol
Dejima A, Takatori H, Miyazawa M, Okafuji H, Hayashi T, Seki A, Nio K, Iida N, Yamada S, Shimakami T, Toyama T, Yamashita T.   +11 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source