Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens [PDF]
, 2017 Trypanosome infection of mammalian hosts leads, within days, to a strong early response against a small, distinct number of parasite proteins. One of these proteins is the variable surface glycoprotein (VSG).
Hemphill, A. +4 more
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Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals [PDF]
, 2018 The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents.
Fairlamb, Alan +10 more
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Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity [PDF]
, 2009 Tien L. Huang +9 more
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Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes [PDF]
, 2016 Kinetochores are multiprotein complexes that couple eukaryotic chromosomes to the mitotic spindle to ensure proper segregation. The model for kinetochore assembly is conserved between humans and yeast, and homologues of several components are widely ...
D’Archivio, Simon, Wickstead, Bill
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New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities [PDF]
, 2011 Sheila Marie Pimentel‐Elardo +8 more
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Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances [PDF]
, 2011 Human African Trypanosomiasis (HAT) also called sleeping sickness is caused by subspecies of the parasitic hemoflagellate Trypanosoma brucei that mostly occurs in sub-Saharan Africa.
Paliwal, Sarvesh K. +2 more
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Synthesis and Optimisation of P3 Substituted Vinyl Sulfone-Based Inhibitors as Anti-Trypanosomal Agents [PDF]
, 2020 A series of lysine-based vinyl sulfone peptidomimetics were synthesised and evaluated for anti-trypanosomal activity against bloodstream forms of T. brucei.
Adler, Nikoletta +4 more
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Establishment of a tRNA over-expression system in Trypanosoma brucei to study the role of post-transcriptional modifications on function. [PDF]
, 2007 Undergraduate Research ScholarshipMayers Summer InternshipDean's Undergraduate Research FundTrypanosomatids are parasitic protozoa which infect millions of humans and animals across the globe every year.
Fill, Mary-Margaret
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Synthesis and pharmaceutical properties of N-acyloxymethyl prodrugs of Allop with potential anti-trypanosomal activity [PDF]
, 2015 María S. Gualdesi +2 more
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