Results 121 to 130 of about 581,138 (251)
Synthesis, antiprotozoal activity and cytotoxicity in U-937 macrophages of triclosan–hydrazone hybrids [PDF]
, 2017 The synthesis and biological activities (cytotoxicity, leishmanicidal, and trypanocidal) of 11 triclosan–hydrazone hybrids are described herein. The structure of the products was elucidated by spectral data (NMR, IR) and mass spectrometric analyses.
Iván D. Vélez +6 more
core +3 more sources
Medicinal Research Reviews, Volume 44, Issue 3, Page 1055-1120, May 2024.Abstract Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of Leishmania protozoa, which are spread by the bite of infected sandflies. There are three main forms of the disease: cutaneous leishmaniasis (CL, the most common), visceral leishmaniasis (VL, also known as kala‐azar, the most serious), and mucocutaneous ...
Miguel Marín +4 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2014 Trypanosoma cruzi has a particular cytoskeleton that consists of a subpellicular network of microtubules and actin microfilaments. Therefore, it is an excellent target for the development of new anti-parasitic drugs.
Dylan L Díaz-Chiguer +6 more
doaj +1 more source
Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies
PLoS Neglected Tropical Diseases, 2012 The image for Figure 1 is incorrect.
Guy Caljon +6 more
openaire +2 more sources
The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice [PDF]
, 2010 The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains.
ALVES, Rosana de Oliveira +6 more
core +3 more sources
Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]
, 2014 It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer +32 more
core +1 more source
Frontiers in Pharmacology, 2018 Moringa is a sole genus of Moringaceae family with 13 species distributed in the tropical and sub-tropical regions. Among them, Moringa peregrina is one of the species which has wide range of traditional, nutritional, industrial, and medicinal values ...
Annadurai Senthilkumar +4 more
doaj +1 more source
Evaluating 5-nitrothiazoles as trypanocidal agents [PDF]
, 2015 OA Monitor ExerciseOA Monitor ExerciseThe growth inhibitory properties of a 5-nitrothiazole series was evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency towards the parasite while exhibiting little ...
Aguilera-Venegas, B +3 more
core +1 more source
Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs [PDF]
, 2017 Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs.
Alsford, Sam +7 more
core +4 more sources