Results 131 to 140 of about 2,622 (160)

In Vitro and in Vivo Anti-Trypanosomal Activities of Methanol Extract of Azadirachta indica Stem-Bark

Tropical Journal of Obstetrics and Gynaecology, 2017
Background: Current chemotherapeutic agents for the treatment of African trypanosomiasis have become largely ineffective, necessitating the search for alternative compounds. The objective of this study was to evaluate in vitro anti-trypanosomal activities of methanol extracts of parts of Azadirachta indica against Trypanosoma brucei rhodesiense ...
Ahmed Hassanali, Grace A Murilla
exaly   +5 more sources

Some of the next articles are maybe not open access.

Related searches:

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

Org. Biomol. Chem., 2014
An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group.
William, Doherty, Jinju, James, Paul, Evans, Laura, Martin, Nikoletta, Adler, Derek, Nolan, Andrew, Knox   +6 more
openaire   +2 more sources

Anti-Trypanosomal Activity of Diarylheptanoids Isolated from the Bark ofAlnus japonica

The American Journal of Chinese Medicine, 2014
The crude extract of Alnus japonica bark exhibited a strong effect on the growth of Trypanosoma brucei. Subsequent chromatographic separation resulted in the isolation of two novel diarylheptanoids, known as alnuside C (2) and alnuside D (3), and three known compounds, 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptan-3(R)-O-β-D-glucopyranoside (1 ...
Nguyen Huu, Tung, Mitsuko, Suzuki, Takuhiro, Uto, Osamu, Morinaga, Kofi D, Kwofie, Naa, Ammah, Kwadwo A, Koram, Frederic, Aboagye, Dominic, Edoh, Taizo, Yamashita, Yasuchika, Yamaguchi, Takao, Setsu, Shoji, Yamaoka, Nobuo, Ohta, Yukihiro, Shoyama   +14 more
openaire   +2 more sources

Anti-trypanosomal activity of cationic N -heterocyclic carbene gold(I) complexes

Molecular and Biochemical Parasitology, 2017
Two gold(I) N-heterocyclic carbene complexes 1a and 1b were tested for their anti-trypanosomal activity against Trypanosoma brucei parasites. Both gold compounds exhibited excellent anti-trypanosomal activity (IC50=0.9-3.0nM). The effects of the gold complexes 1a and 1b on the T. b. brucei cytoskeleton were evaluated.
Isabel, Winter, Julia, Lockhauserbäumer, Gertrud, Lallinger-Kube, Rainer, Schobert, Klaus, Ersfeld, Bernhard, Biersack   +5 more
openaire   +2 more sources

Coordination of nitro-thiosemicarbazones to ruthenium(II) as a strategy for anti-trypanosomal activity improvement

European Journal of Medicinal Chemistry, 2010
Complexes [RuCl(H4NO(2)Fo4M)(bipy)(dppb)]PF(6) (1), [RuCl(H4NO(2)Fo4M)(Mebipy)(dppb)]PF(6) (2), [RuCl(H4NO(2)Fo4M)(phen)(dppb)]PF(6) (3), [RuCl(H4NO(2)Ac4M)(bipy)(dppb)]PF(6) (4), [RuCl(H4NO(2)Ac4M)(Mebipy)(dppb)]PF(6) (5) and [RuCl(H4NO(2)Ac4M)(phen)(dppb)]PF(6) (6) with N(4)-methyl-4-nitrobenzaldehyde thiosemicarbazone (H4NO(2)Fo4M) and N(4)-methyl-4-
Claudia, Rodrigues, Alzir A, Batista, Javier, Ellena, Eduardo E, Castellano, Diego, Benítez, Hugo, Cerecetto, Mercedes, González, Letícia R, Teixeira, Heloisa, Beraldo   +8 more
openaire   +2 more sources

New anti-trypanosomal active prenylated compounds from African propolis

Phytochemistry Letters, 2014
The secondary metabolite composition of propolis has always been corroborated on the vegetation surrounding the bee hive. The plants chosen by the bees seem to exhibit activity to protect the hive from the surrounding environmental pressures which include protozoal attack. Two new stilbene compounds were isolated from Ghanian propolis which were formed
Sultan Almutairi, Ben Eapen, Sai Maneesha Chundi, Adnan Akhalil, Weam Siheri, Carol Clements, James Fearnley, David G. Watson, RuAngelie Edrada-Ebel   +8 more
openaire   +1 more source

Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators

Bioorganic & Medicinal Chemistry, 2013
Iron is an essential growth component in all living organisms and plays a central role in numerous biochemical processes due to its redox potential and high affinity for oxygen. The use of iron chelators has been suggested as a novel therapeutic approach towards parasitic infections, such as malaria, sleeping sickness and leishmaniasis.
Gehrke, Sebastian S, Pinto, Erika G, Steverding, Dietmar, Pleban, Karin, Tempone, Andre G, Hider, Robert C, Wagner, Gerd K   +6 more
openaire   +3 more sources

The Inhibition of the Anti-Trypanosomal Activity of Arsenoso Compounds and Acridines by Esters and Amides of Organic Acids

The Journal of Immunology, 1948
Summary Esters and amides of different isocyclic and heterocyclic acids were found to antagonize in vitro the immobilization of T. equiperdum by arsenoso compounds and acriflavine. The corresponding acids did not exert any inhibitory effect.
W L, SCHLEYER, R J, SCHNITZER
openaire   +2 more sources

Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure–activity relationship study

Bioorganic & Medicinal Chemistry, 2010
Leishmaniasis and Chagas' disease constitute a relevant health and socio-economic problem in Latin America, Africa, and Asia. The therapeutic interventions rely on inefficient and highly toxic drugs with systemic side effects in patients. Considering the multiple biological activities of the calcium channel blockers and the high versatility of 1,4 ...
Juliana Q, Reimão, Marcus T, Scotti, André G, Tempone   +2 more
openaire   +2 more sources

Small molecules with anti-trypanosomal and anti-leishmanial activity [PDF]

, 2012
Parasitic diseases such as Human African Trypanosomiasis (HAT), Chagas disease and Leishmaniasis cause thousands of fatalities each year. Current chemotherapy is based on drugs discovered over 60 years ago that are expensive and difficult to administer. The drug-pipeline is virtually dry and the trickle of inhibitors that are in development are largely
openaire