Results 121 to 130 of about 2,622 (160)

Anti-Trypanosomal Activity of African Medicinal Plants: A Review Update

Journal of Ethnopharmacology, 2014
African trypanosomiasis is one of the neglected tropical diseases caused by different species of trypanosomes that affect both human and livestock with devastating consequences in the continent. Most of the affected populations commonly use traditional medicinal plants for the treatment of the disease.
Aminu Mohammed, Murtala Bindawa Isah, Mohammed Auwal Ibrahim   +2 more
exaly   +3 more sources

Evaluation of the Anti-Trypanosomal Activity of Tyropeptin A

Planta Medica, 2006
The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times lower for bloodstream-form ...
Steverding, Dietmar, Pemberton, Alexander J., Royle, Howard, Spackman, Robert W., Rivett, A. Jennifer   +4 more
openaire   +3 more sources

Anti-trypanosomal activities of DNA topoisomerase inhibitors

Acta Tropica, 2005
Only four drugs are available for chemotherapy of human African sleeping sickness with undesirable toxic side effects. The development of new anti-trypanosomal drugs is, therefore, urgently required. In this study, 15 DNA topoisomerase inhibitors, including approved anti-cancer drugs, were tested for in vitro activity against bloodstream forms of ...
Deterding, Alexander, Dungey, Fiona A., Thompson, Katy-Anne, Steverding, Dietmar   +3 more
openaire   +3 more sources

Improving Anti-Trypanosomal Activity of Alkamides Isolated From Achillea fragrantissima

Fìtoterapìâ, 2018
In previous studies the aerial parts of Achillea fragrantissima were found to have substantial antileishmanial and antitrypanosomal activity. A bioassay-guided fractionation of a dichloromethane extract yielded the isolation of the essential anti-trypanosomal compounds of the plant. Seven sesquiterpene lactones (including Achillolide-A), two flavonoids,
Ulrike Holzgrabe, Omar Hamarsheh, Michael Berninger   +2 more
exaly   +3 more sources

A Chlorodiazirine Analog of Pentamidine with Anti-Trypanosomal Activity

The Journal of Parasitology, 2000
A chlorodiazirine derivative of pentamidine was synthesized and tested for anti-trypanosomal activity using EATRO stock 164 trypanosomes in cell culture. Anti-trypanosomal activity was measured as a decrease in [3H]hypoxanthine incorporation by the organisms.
A C, Nichols, K L, Yielding, S A, Agbe
openaire   +2 more sources

Anti‐trypanosomal activity of Alchornia cordifolia

Phytotherapy Research, 1987
AbstractExtracts of the leaves and fruits of Alchornia cordifolia (ACL2 and ACF2) were found to inhibit the growth of Trypanosoma brucei brucei in rats. Purification of ACL2 and ACF2 yielded fractions ACL3, ACL4 and ACF3, ACF4, respectively, which were inactive. However fractions ACF3 and ACF4 were found to be toxic in rats.
S. A. O. Agbe, B. Oguntimein
openaire   +1 more source

Anti-trypanosomal Activity of Helenalin and Some Structurally Related Sesquiterpene Lactones

Planta Medica, 2002
The anti-trypanosomal activity of six sesquiterpene lactones (helenalin, mexicanin I, 11alpha,13-dihydrohelenalin acetate, chamissonolide, ivalin and isoalantolactone) against the African Trypanosoma brucei rhodesiense and American T. cruzi was investigated.
Thomas J, Schmidt, Reto, Brun, Günter, Willuhn, Sami A, Khalid   +3 more
openaire   +2 more sources

Anti-trypanosomal activities and structural chemical properties of selected compound classes

Parasitology Research, 2014
Potent compounds do not necessarily make the best drugs in the market. Consequently, with the aim to describe tools that may be fundamental for refining the screening of candidates for animal and preclinical studies and further development, molecules of different structural classes synthesized within the frame of a broad screening platform were ...
Alicia, Ponte-Sucre, Heike, Bruhn, Tanja, Schirmeister, Alexander, Cecil, Christian R, Albert, Christian, Buechold, Maximilian, Tischer, Susanne, Schlesinger, Tim, Goebel, Antje, Fuß, Daniela, Mathein, Benjamin, Merget, Christoph A, Sotriffer, August, Stich, Georg, Krohne, Markus, Engstler, Gerhard, Bringmann, Ulrike, Holzgrabe   +17 more
openaire   +2 more sources

Synthesis and anti-trypanosomal activity of 3′-fluororibonucleosides derived from 7-deazapurine nucleosides

Bioorganic & Medicinal Chemistry Letters, 2021
Trypanosoma brucei parasites cause Human African Trypanosomiasis and the current drugs for its treatment are often inefficient and toxic. This urges the need to development of new antitrypanosomal agents. We report the synthesis and biological profiling of 3'-deoxy-3'-fluororibonucleosides derived from 7-deazaadenine nucleosides bearing diverse ...
Van Hai Nguyen, Michal Tichý, Samanta Rožánková, Radek Pohl, A. Michael Downey, Eva Doleželová, Eva Tloušťová, Martina Slapničková, Alena Zíková, Michal Hocek   +9 more
openaire   +2 more sources

Computer assisted design of potentially active anti-trypanosomal compounds

Journal of Molecular Structure: THEOCHEM, 2002
Abstract A computer assisted molecular modeling was used to design molecules having a shape complementary to the active site of glutathione reductase (GR) and trypanothione reductase (TR). The designed 5-nitro compound derivatives, were obtained from structural knowledge gleaned on glutathione (GSSG), trypanothione (T[S]2) and GSP disulfide ...
Paulino, Margot, Iribarne, Federico, Hansz, María, Vega, Mauricio, Seoane, Gustavo, Cerecetto, Hugo, Di Maio, Rossanna, Caracelli, Ignez, Zukerman-Schpector, Julio, Olea, Claudio, Stoppani, Andrés O.M., Berriman, Mathew, Fairlamb, Alan H., Tapia, Orlando   +13 more
openaire   +2 more sources