Anti-trypanosomal activities of polyherbal formulation of Lawsonia inermis and Azadiractha indica when combined with diminazene aceturate [PDF]
, 2021 Abdulfatai Aremu +6 more
openalex +1 more source
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]
, 2015 Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Alonso-Padilla, Julio +20 more
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Antioxidant and Anti-trypanosomal Activities of the Allium Sativum (Garlic) Bulb Aqueous Extract on Trypanosoma Congolense Infected Mice [PDF]
, 2022 Fatima Mohammad Madaki +6 more
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Trypanosoma equiperdum in the horse : a neglected threat? [PDF]
, 2018 Dourine is a contagious disease caused by Trypanosoma equiperdum that is transmitted directly from animal to animal during coitus. Dourine is known as an important disease in many countries, and it threatens equidae worldwide.
Ahmed, Y +6 more
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Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals [PDF]
, 2018 The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents.
Fairlamb, Alan +10 more
core +2 more sources
Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]
, 1994 . Lipoprotein lipase (LPL) and glycolipidanchored cAMP-binding ectoprotein (Gcel) are modified by glycosyl-phosphatidylinositol (GPI) in rat adipocytes, however, the linkage is potentially unstable. Incubation of the cells with either insulin (0.1-30 nM)
Bandlow, Wolfhard +3 more
core +3 more sources
Trypanocidal potentials of Jatropha curcas L. 1753 leaf extracts and fractions in vivo
Pharmacological Research - Modern Chinese MedicineIntroduction: Trypanosomiasis is a debilitating parasitic disease affecting both humans and animals, leading to substantial economic losses in the livestock sector due to reduced productivity and increased mortality.
Haolat Yusuf +5 more
doaj +1 more source
Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei [PDF]
, 2015 Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
De Koning, Harry P. +2 more
core +1 more source
Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens [PDF]
, 2017 Trypanosome infection of mammalian hosts leads, within days, to a strong early response against a small, distinct number of parasite proteins. One of these proteins is the variable surface glycoprotein (VSG).
Hemphill, A. +4 more
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