Results 41 to 50 of about 3,431,935 (293)

In silico Pharmacokinetic, Bioactivity and Toxicity Evaluation of Some Selected Anti-Ulcer Agents

, 2017
Peptic ulcer is a major health burden that recognized as a group of upper gastro-intestinal tract disorders. The aim of the therapy is to provide relieve from pain and prevent ulcer complications.
Shashank Shekhar Mishra, Chandra Shekhar Sharma, Hamendra Pratap Singh, Neeraj Kumar, Harshda Singh   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pressure ulcer related pain in community populations: a prevalence survey. [PDF]

, 2014
BACKGROUND: Pressure ulcers are costly to the healthcare provider and can have a major impact on patient's quality of life. One of the most distressing symptoms reported is pain.
McGinnis, Elizabeth, Coleman, S, McGinnis, E, Wilson, L, Briggs, Michelle, Michelle Collinson, Nelson, EA, Susanne Coleman, Briggs, M; id_orcid, Collinson, Michelle, Stevenson, Rebecca, Dealey, C, Stubbs, N, E Andrea Nelson, Jane Nixon, Dealey, Carol, Michelle Briggs, Briggs, M, Nixon, J, Stevenson, R, Lyn Wilson, Nikki Stubbs, Brown, Julia, Nelson, E Andrea; id_orcid, Collinson, M, Coleman, Susanne, Elizabeth McGinnis, Nixon, Jane, Rebecca Stevenson, Wilson, Lyn, Julia Brown, Stubbs, Nikki, Carol Dealey, Brown, J   +33 more
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Comparing the ventilator-associated pneumonia incidence when pantoprazole or ranitidine is used for stress ulcer prophylaxis in critically ill adult patients

International Archives of Health Sciences, 2019
Aim: Prophylaxis against stress ulcer in mechanically ventilated patients is one of the causes for ventilator-associated pneumonia (VAP). Our aim was evaluating the effect of intravenous pantoprazole and ranitidine in the incidence of VAP in critically ...
Reza Nikandish, Farid Zand, Golnar Sabetian, Hajar Faghihi, Mansour Masjedi, Behzad Maghsoudi, Afsaneh Vazin, Mohammad Ghorbani, Elham Asadpour   +8 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Reduced risk of gastrointestinal bleeding associated with eupatilin in aspirin plus acid suppressant users: nationwide population-based study [PDF]

The Korean Journal of Internal Medicine
Background/Aims Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the
Hyun Seok Lee, Ji Hyung Nam, Dong Jun Oh, Yeo Rae Moon, Yun Jeong Lim   +4 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Subeschar culture using a punch instrument in unstageable wounds

Archives of Plastic Surgery, 2020
Background A patient’s overall condition sometimes does not allow for the complete removal of a dead eschar or injured slough in cases involving a pressure-injury skin lesion.
Han Byul Jung, Yong Jig Lee
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source