Results 151 to 160 of about 1,966,260 (257)

Targeting pyruvate kinase M2 (PKM2) reduces T cell pathogenicity in multiple sclerosis. [PDF]

EBioMedicine
Ellmeier E, Schnabl A, Meissel J, Stracke A, Rittchen S, Stöger L, Passegger CA, Schwarzl L, Tafrali C, Demjaha R, Martinez-Serrat M, Kaiser T, Zeiler LC, Seifried K, Topler A, Klemen I, Heschl B, Damulina A, Runtsch MC, Fessler J, Hofer E, Khalil M, Angiari S.   +22 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Efficacy of belimumab in patients with SLE and haematological manifestations: retrospective analysis from the BeRLiSS 2.0 cohort. [PDF]

Lupus Sci Med
Hulej G, Arru F, Bianchi B, Bortoluzzi A, Brussino L, Castrignanò P, Cauli A, Cavagna L, Chessa E, Chiara E, De Angelis R, De Marchi G, Depascale R, Di Carlo M, Emmi G, Galvagni I, Gasparotto M, Gatto M, Gerli R, Govoni M, Lo Gullo A, Nano A, Negrini S, Noviello S, Orsolini G, Pazzola G, Piga M, Quartuccio L, Rossini M, Salvarani C, Silvagni E, Silvestri E, Tamussin M, Tizian M, Tomietto P, Urban ML, Vacca A, Vesentini F, Bracalenti M, Ramonda R, Doria A, Iaccarino L, Zen M.   +42 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Peroxisome-derived ether lipids regulate lysosomal exocytosis. [PDF]

EMBO J
Chen L, Henn D, Dong Z, Liang J, Wielenga A, Vale G, Burugula B, Zou J, Krishnan Y, McDonald JG, Kitzman J, Li M.   +11 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration. [PDF]

PLoS Pathog
Hart DJ, Uddin MJ, Dodd RJ, Brovero SG, Fleming C, Moreau GB, Natale NR, Naz F, Mann BJ, Sutherland TE, Allen JE, Day AJ, Petri WA.   +12 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Immunonutritional Indices, Inflammatory Markers, and Thyroid-Related Parameters in Adults with Hashimoto's Thyroiditis. [PDF]

Nutrients
Yilmaz Onal H, Aktas S, Yuksel A, Tuncalı Yaman T, Keskin O, Uzun H.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source