Results 131 to 140 of about 7,382,706 (304)
The reports for 1857 and 1858 are published in one volume, with a common title-page and continuous pagination. The report for 1860 has cover-title "The anti-slavery history of the John-Brown year; being the twenty-seventh annual report of the American ...
American Anti-Slavery Society.
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Türk Biyokimya DergisiReference change value (RCV) is an objective tool that indicates whether the change between consecutive measurements is clinically significant. This study aimed to determine the instrument-specific RCVs of thyroid-stimulating hormone (TSH), free ...
Bildirici Mehmet Akif +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Annual report of Anti-Saloon League of Oregon for fiscal year ending
Title varies slightly.1922 lacks title.This archived document is maintained by the State Library of Oregon. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the State Library of Oregon Oregoniana ...
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Law as an anti-value.Justice, violence and suffering in the logic of becoming
Anthropology Today, 2014 Anthropologists are chronologically only the latest to have adopted justice (and injustice) as an object of (critical) inquiry. Even among anthropologists, however, the radical critical cry that law is the instrument par excellence of control and repression, has today fallen out of fashion.
openaire +2 more sources
Talk: Values In Conflict: Happiness Vs Meaning
, 2022 Video: 1 hr. 40 sec.What happens when the desire for happiness conflicts with a life of meaning? Professor Dr. Tal Ben-Shahar, expert in positive psychology who has taught one of Harvard's largest classes, states that his purpose "is to ...
core