Results 61 to 70 of about 4,644,977 (251)

Anti-Vascular Endothelial Growth Factor Therapy as an Alternative or Adjunct to Pan-Retinal Photocoagulation in Treating Proliferative Diabetic Retinopathy: Meta-Analysis of Randomized Trials

Frontiers in Pharmacology, 2020
AimTo compare anti-vascular growth factor (anti-VEGF) pharmacotherapy with pan-retinal photocoagulation (PRP) for proliferative diabetic retinopathy (PDR).MethodPubMed, Embase, Medline, the ClinicalTrials.gov and the Cochrane Central Register of ...
Shuang Gao, Zhongjing Lin, Xi Shen
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

, 2018
The survival benefit of anti-vascular endothelial growth factor (VEGF) therapy in metastatic colorectal cancer (mCRC) patients is limited to a few months because of acquired resistance.
Rahbari, N. N., Ho, William W., Kedrin, D., Duda, D. G., Boucher, Y., Nia, H. T., Daubriac, J., Martin, J. D., Huang, Y., Reissfelder, C., Fukumura, D., Clark, J. W., Chen, I., Heishi, T., Incio, J., Edrich, C. M., Grodzinsky, Alan J, Liu, H., Weitz, J., Jung, K., Maimon, N., Jain, R. K.   +21 more
core   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

LASER PHOTOCOAGULATION VERSUS INTRAVITREAL ANTI VEGF AGENTS FOR TREATMENT OF RETINOPATHY OF PREMATURITY [PDF]

Egyptian Journal of Clinical Ophthalmology
Background: Early birth and various oxygen techniques can cause retinopathy of prematurity(ROP), a widespread childhood visual problem. An aggressive ROP (A-ROP) differs from normalprogression. Diode laser replaced cryotherapy.
Aldghaimy, A.
doaj   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

New opportunities in management of patients with retinopathy prematurity (literature review and analysis of own data)

Российский офтальмологический журнал, 2020
Insufficient effectiveness of laser coagulation of the avascular retinal areas in retinopathy of prematurity (ROP) plus-disease in zone I and aggressive posterior retinopathy of prematurity (APROP) requires new treatment approaches, based on the ...
L. A. Katargina, E. N. Demchenko
doaj   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Comparative Efficacy of Second-line Anti-VEGF Continuation and Anti-EGFR Switch Strategies in RAS Wild-type Metastatic Colorectal Cancer Patients Progressing on First-line Anti-VEGF Therapy: A Retrospective Single-center Study

Journal of Oncological Sciences
Objective: The optimal selection of second-line biological therapy remains unclear in patients with RAS wild-type metastatic colorectal cancer (mCRC) who develop disease progression following first-line anti-vascular endothelial growth factor (VEGF ...
Simay ÇOKGEZER, Esma Nur SAĞLAM, İrem Sena BAYRAK, Muhammet ŞENKAL, Hamza Uğur BOZBEY, Didem TAŞTEKİN, Senem KARABULUT   +6 more
doaj   +1 more source