Results 191 to 200 of about 2,259,235 (294)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Novel anti-virulence strategy against <i>Helicobacter pylori</i> using <i>Lactiplantibacillus plantarum</i> cell-free supernatants. [PDF]

Front Microbiol
El-Sayed NR, Samir R, Abdel-Hafez LJM, Ibrahim K, Binsuwaidan R, Selim H, Ramadan MA.   +6 more
europepmc   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Disarming Campylobacter hepaticus - the in vitro and in vivo efficacy of natural antimicrobials as anti-virulence proxies. [PDF]

Poult Sci
Imbrea AM, Balta I, Morariu S, Stef L, Pet I, Crista CL, Stef D, Morariu F, Corcionivoschi N.   +8 more
europepmc   +1 more source

The Microbiome as a Mirror: Distinguishing Healthy Individuals From Chronic Constipated Patients and Identifying Those With Hidden Psychiatric Burden

Microbiota Medicine Research, EarlyView.
Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi, Ting Yu, Weichen Liu, Ya Jiang, Die Chen, Li Gao, Hui Li, Yurong Tang   +7 more
wiley   +1 more source

Role of cell-associated and secretion-independent virulence factors of Pseudomonas aeruginosa in microbial keratitis and anti-virulence therapeutic strategies. [PDF]

Eur J Clin Microbiol Infect Dis
Akter T, Islam S, Khan S, Zillur Rahman KM, Lubna MA, Stapleton F, Willcox M.   +6 more
europepmc   +1 more source

Antifungal and anti-virulence activities of cinnamon, thyme, and clove essential oils against <i>Candida</i> species. [PDF]

Front Pharmacol
Ahaik I, Nunez-Rodriguez JC, Abelló-Cros S, Yanes O, Bouhdid S, Gabaldón T.   +5 more
europepmc   +1 more source

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Beyond antibiotics: a new anti-virulence strategy combating ESBL-producing Klebsiella pneumoniae by targeting periplasmic trehalase. [PDF]

BMC Microbiol
Zhang Q, Zhang Y, Cong S, Yuan Y, Wang Y.   +4 more
europepmc   +1 more source

Discovery of edodine, a natural compound from Lentinula edodes with antibacterial activity for the biological control of fire blight pathogen Erwinia amylovora

Pest Management Science, EarlyView.
Novel edodine was identified from Lentinula edodes HK761, exhibiting biocontrol potential against fire blight by affecting motility, intracellular ATP level, and cell division of Erwinia amylovora. Abstract BACKGROUND In the search for biological resources with antibacterial activity against Erwinia amylovora, the culture filtrate of Lentinula edodes ...
Yeong Seok Kim, Jae Woo Han, Bomin Kim, Chunggeon Lee, Daeui Park, Jaehyuk Choi, Gyung Ja Choi, Hun Kim   +7 more
wiley   +1 more source