D-alanylation of lipoteichoic acids inhibitor provides anti-virulence and anti-resistance effects against methicillin-resistant <i>Staphylococcus epidermidis</i>. [PDF]
Mahé A +10 more
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Proven anti-virulence therapies in combating methicillin- and vancomycin-resistant <i>Staphylococcus aureus</i> infections. [PDF]
Bakeer W +8 more
europepmc +1 more source
A chionodracine-derived peptide, KHS-Cnd, as an anti-virulence agent against multidrug-resistant <i>Acinetobacter baumannii</i> clinical strains. [PDF]
Artini M +6 more
europepmc +1 more source
Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae [PDF]
While antimicrobial resistance (AMR) is seen in both Neisseria gonorrhoeae and Neisseria meningitidis, the former has become resistant to commonly available over-the-counter antibiotic treatments.
Keith A Stubbs +2 more
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Preparation and Pharmacokinetic Characterization of an Anti-Virulence Compound Nanosuspensions [PDF]
Antibiotic resistance has become a worldwide public health threat due to the rapid evolution and spread of antibiotic-resistant bacteria. CCG-211790 is a novel anti-virulence compound that does not kill bacteria but could ameliorate human diseases by inhibiting expression of virulence factors, thereby applying less selection pressure for antibiotic ...
Honglan Shi, Feng Qi
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Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents [PDF]
Recent years have witnessed a dramatic increase in bacterial antimicrobial resistance and a decline in the development of novel antibiotics. New therapeutic strategies are urgently needed to combat the growing threat posed by multidrug resistant bacterial infections.
Jason Paxman +2 more
exaly +4 more sources
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Quorum Quenching in Anti-virulence Therapy
2023The quest for new anti-virulence medications has been sparked by the rising antibiotic resistance rates of pathogenic bacteria. By interfering with vital components of bacteria, such as their cell walls, nucleic acids and protein biosynthesis, conventional antibiotics kill or restrict bacterial growth.
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Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy [PDF]
Staphylococcus aureus is an opportunistic pathogen and the leading cause of a wide range of severe clinical infections. The range of diseases reflects the diversity of virulence factors produced by this pathogen. To establish an infection in the host, S. aureus expresses an inclusive set of virulence factors such as toxins, enzymes, adhesins, and other
Hui-Min Neoh, Cin Kong, Sheila Nathan
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Anti-Virulence Factor Therapeutics
2017There is little doubt that the startling increases in the prevalence and diversity of antibiotic-resistant bacterial pathogens, which are leading to the significant loss of effective antibiotics to treat bacterial infections, are one of the most, if not the most, critical threats to the health of the entire world population.
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