Results 91 to 100 of about 70,197 (213)

A Tale of Two Conditions: 50 Years of Chronic Illness and Cancer From a Nursing Perspective

Journal of Advanced Nursing, EarlyView.
ABSTRACT Introduction In this commentary, I consider the disparity between the care we see as a necessity for cancer patients and the lack of care we afford to many persons with chronic disease. Background I ground my arguments in my own clinical practice and research experiences over a 50‐year period augmented by reference to available literature ...
Sally Thorne
wiley   +1 more source

Cumulative incidence and treatment effectiveness of low bone mineral density among people living with HIV in Iran (2021–2023)

AIDS Research and Therapy
Background The introduction of antiretroviral therapy (ART) has significantly improved the life expectancy of people living with HIV (PLHIV), leading to an increased prevalence of age-related comorbidities such as osteoporosis.
Hamidreza Rashidi, Soheil Mehmandoost, Noushin Fahimfar, Seyed Mohammad Hosseinian, Mohammad Reza Shakibi, Tarlan Hasan Aghaei, Farzaneh Yazdi Yahaabadi, Pouriya Salajegheh, Willi Mcfarland, Afshin Ostovar, Hamid Sharifi   +10 more
doaj   +1 more source

Out-of-pocket Expenditure and its Impact on the Quality of Life among Patients Attending the Anti-retroviral Therapy Centre of a Tertiary Care Hospital in Kolkata [PDF]

Healthline
Introduction: Out-of-pocket expenditure (OOPE) has a negative impact on Quality of life (QoL) of People Living with HIV (PLHIV)which can increase the risk of slipping into poverty. Objectives: Primary Objective of this study was to estimate the burden of
Mamunur Rashid, Dipendra Narayan Goswami, Kuntala Ray, Mausumi Basu, Aparajita Mondal, Abhipsa Dey   +5 more
doaj   +1 more source

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]

, 2017
Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Albert, Brice J, Barnes, Alexander B, Kyei, George B, Marshall, Garland R, Niu, Austin, Ramani, Rashmi, Ratner, Lee, Wender, Paul A, Williams, Robert M   +8 more
core   +2 more sources

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Public Health Achievements in Rwanda: A 21st Century Transformation

Public Health Challenges, Volume 5, Issue 2, June 2026.
This narrative review examines Rwanda's post‐2000 public health transformation using the WHO health system building blocks. It shows how strategic governance, universal health coverage via mutuelle de santé, community health workers, and digital health tools have driven substantial gains in maternal/child health, infectious disease control, and ...
Niyibizi Julius, Mugisha John, Nizeyimana Emmanuel   +2 more
wiley   +1 more source

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. [PDF]

, 2011
Excessive demands on the protein-folding capacity of the endoplasmic reticulum (ER) cause irremediable ER stress and contribute to cell loss in a number of cell degenerative diseases, including type 2 diabetes and neurodegeneration.
Austgen, Kathryn, Curran, Tom, Johnson, Emily T, Oakes, Scott A, Park, Tae-Ju   +4 more
core  

Targeting self-renewal pathways in myeloid malignancies [PDF]

, 2013
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core   +2 more sources

HIV-1 integrase resistance in the context of antiretroviral therapy in paediatric patients ‒ Northeast Brazil

Brazilian Journal of Infectious Diseases
Introduction: Antiretroviral drug resistance poses a challenge to therapy efficacy. Although Integrase Strand Transfer Inhibitors (INSTIs) have a high genetic barrier to resistance, few studies in Brazil have focused on INSTI resistance. This study aimed
Aldicléya Lima Luz, Élcio Leal, Kledoaldo Lima, Mikhael Morais de Souza, Michelle Lima de Carvalho Silva, Mayra Moura Lima, Paloma Gomes Tavares Sette, Yasmim Leandra Moura de Almeida, Heloísa Ramos Lacerda de Melo   +8 more
doaj   +1 more source

Fighting HIV/AIDS: Reconfiguring the State? [PDF]

, 2008
The author wishes to thank the anonymous reviewers of the article and the ESRC for funding part of this ...
AIDS Campaign Team for Africa (ACTAfrica), Brown J. C., Chirambo K., Harman S., Harrison G., Peet R., Poku N. K., Schoepf B. G., Sophie Harman, UNAIDS   +9 more
core   +1 more source