Results 111 to 120 of about 69,808 (218)

Determining cellular and biochemical function of a novel adhesion molecule in kidneys. [PDF]

, 2016
Acute kidney injury is an abrupt loss of kidney function that develops in short time with limited effective treatments other than kidney transplantation. We have identified TMIGD1 (Transmembrane immuno- globulin domain 1) as a novel receptor expressed in
Arafa, Emad
core   +1 more source

Fighting HIV/AIDS: Reconfiguring the State? [PDF]

, 2008
The author wishes to thank the anonymous reviewers of the article and the ESRC for funding part of this ...
AIDS Campaign Team for Africa (ACTAfrica), Brown J. C., Chirambo K., Harman S., Harrison G., Peet R., Poku N. K., Schoepf B. G., Sophie Harman, UNAIDS   +9 more
core   +1 more source

Biologically Younger Individuals, as Identified by MARK‐AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age

Aging Cell, Volume 25, Issue 3, March 2026.
Using sets of biomarkers of human ageing, a ‘bioage’ score was established allowing calculation of ‘age difference’ (bioage minus chronological age). Age difference, but not chronological age, was correlated with levels of HDL, Vitamin D, and CD3+ CD4+/CD45+ ratio, with biologically younger subjects displaying favourable values, pointing to a role of ...
María Moreno‐Villanueva, Michael Junk, Grażyna Mosieniak, Ewa Sikora, Miriam Capri, Paolo Garagnani, Chiara Pirazzini, Nicolle Breusing, Jürgen Bernhardt, Christiane Schön, María Blasco, Gerben Zondag, Florence Debacq‐Chainiaux, Beatrix Grubeck‐Loebenstein, Birgit Weinberger, Simone Fiegl, Eugenio Mocchegiani, Marco Malavolta, Robertina Giacconi, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Daniela Gradinaru, Martijn E. T. Dollé, Eugène Jansen, Michel Salmon, Peter Kristensen, Helen Griffiths, Claude Libert, Valerie Vanhooren, Andreas Simm, Duncan Talbot, Paola Caiafa, Maria Giulia Bacalini, Michele Zampieri, Bertrand Friguet, Isabelle Petropoulos, P. Eline Slagboom, Rudi Westendorp, Antti Hervonnen, Mikko Hurme, Richard Aspinall, Sheila Govind, Daniela Weber, Wolfgang Stuetz, Jan H. J. Hoeijmakers, Iuliia Gavriushina, Oliver R. Sampson, Gastone Castellani, Michael R. Berthold, Tilman Grune, Claudio Franceschi, Alexander Bürkle   +52 more
wiley   +1 more source

Impact of interrupting antiretroviral therapy started during primary HIV-1 infection on plasma neurofilament light chain protein, a marker of neuronal injury: The SPARTAC trial

Journal of Virus Eradication
Objective: Antiretroviral therapy (ART)-conferred suppression of HIV replication limits neuronal injury and inflammation. ART interruption tests efficacy in HIV cure trials and viral rebound after ART interruption may induce neuronal injury.
Jasmini Alagaratnam, Wolfgang Stöhr, Elizabeth Hamlyn, Kholoud Porter, Jamie Toombs, Amanda Heslegrave, Henrik Zetterberg, Magnus Gisslén, Jonathan Underwood, Mauro Schechter, Pontiano Kaleebu, Giuseppe Tambussi, Sabine Kinloch, Jose M. Miro, Anthony D. Kelleher, Abdel Babiker, John Frater, Alan Winston, Sarah Fidler   +18 more
doaj   +1 more source

Targeting MCL‐1 and MAPK overcomes venetoclax resistance in FLT3‐ITD‐positive AML cells harbouring activating PTPN11 (SHP‐2) mutations

British Journal of Haematology, Volume 208, Issue 3, Page 905-915, March 2026.
Summary Venetoclax (VEN)‐based therapies have improved the treatment of acute myeloid leukaemia (AML); however, the emergence of resistance remains a major limitation. Mutations in protein tyrosine phosphatase (PTP) non‐receptor type 11 (PTPN11) and FMS like tyrosine kinase 3 with internal tandem duplication (FLT3‐ITD) are common in resistant patients ...
Maximilian Fleischmann, Ole Hansen, Diana Voigtländer, Julia Bechwar, Lenny‐Joseph Schwietzer, Sanja Bahr, Ulf Schnetzke, Mike Fischer, Florian H. Heidel, Tina M. Schnöder, Jörg P. Müller, Andreas Hochhaus, Sebastian Scholl   +12 more
wiley   +1 more source

Defining and Predicting HIV Immunological Non-Response: A Multi-Definition Analysis from an Indonesian Cohort

Viruses
Immunological non-response (INR) to antiretroviral therapy (ART) is a critical concern for PLHIV, characterized by inadequate CD4+ T-cell recovery despite virological suppression.
Brian Eka Rachman, Yehuda Tri Nugroho Supranoto, Soraya Isfandiary Iskandar, Tri Pudy Asmarawati, Siti Qamariyah Khairunisa, Muhammad Vitanata Arfijanto, Usman Hadi, Muhammad Miftahussurur, Nasronudin Nasronudin, Masanori Kameoka, Retno Pudji Rahayu, Afif Nurul Hidayati   +11 more
doaj   +1 more source

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites.

PLoS ONE, 2015
Cancer cells have a high iron requirement and many experimental studies, as well as clinical trials, have demonstrated that iron chelators are potential anti-cancer agents.
Eliška Potůčková, Jaroslav Roh, Miloslav Macháček, Sumit Sahni, Ján Stariat, Vít Šesták, Hana Jansová, Pavlína Hašková, Anna Jirkovská, Kateřina Vávrová, Petra Kovaříková, Danuta S Kalinowski, Des R Richardson, Des R Richardson, Tomáš Šimůnek   +14 more
doaj   +1 more source

Evaluation of Drug–Drug Interaction Potential Between the Oral Antibiotic Zoliflodacin and the CYP3A4 Inhibitor Itraconazole: A Phase 1 Study in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Zoliflodacin is a first‐in‐class oral spiropyrimidinetrione antibiotic being developed for patients with uncomplicated gonorrhea, including those infected with multidrug‐resistant strains. Because zoliflodacin is metabolized by cytochrome P450 3A4 (CYP3A4), concomitant administration with a CYP3A inhibitor has the potential to increase ...
Alison Luckey, Kajal B. Larson, Noha Rayad, Markus Heep, Sophie Delhomme, Gabrielle Kornmann, John P. Mueller, John P. O'Donnell, Seamus O'Brien, Rainard Fuhr, Jean‐Yves Gillon   +10 more
wiley   +1 more source

Utilização dos registros de dispensação da farmácia como indicador da não-adesão à terapia anti-retroviral em indivíduos infectados pelo HIV Pharmacy records as an indicator of non-adherence to antiretroviral therapy by HIV-infected patients

Cadernos de Saúde Pública, 2009
Este estudo teve como objetivos avaliar os registros de dispensação de anti-retrovirais (ARV) por um período de 12 meses após a primeira prescrição e determinar os fatores associados com a retirada irregular ou abandono em dois serviços públicos de ...
Raquel Regina de Freitas Magalhães Gomes, Carla Jorge Machado, Francisco de Assis Acurcio, Mark Drew Crosland Guimarães   +3 more
doaj   +1 more source

Cooperative research and development opportunities with the National Cancer Institute [PDF]

The Office of Technology Development (OTD) of the National Cancer Institute (NCI) is responsible for negotiating Cooperative Research and Development Agreements (CRADAs), whereby the knowledge resulting from NCI investigators' government-sponsored ...
Sybert, Kathleen
core   +1 more source