Results 111 to 120 of about 24,764 (229)

Emerging Antiarrhythmic Drugs for Atrial Fibrillation. [PDF]

Int J Mol Sci, 2022
Saljic A, Heijman J, Dobrev D.
europepmc   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in the Zebrafish Heart. [PDF]

Int J Mol Sci, 2023
De la Cruz A, Wu X, Rainer QC, Hiniesto-Iñigo I, Perez ME, Edler I, Liin SI, Larsson HP.   +7 more
europepmc   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

A Simple Dual-Track HPLC-UV Methodology for Monitoring Primary Antiarrhythmic Drugs and Their Active Metabolites in Serum. [PDF]

Pharmaceuticals (Basel)
Kunicki PK, Drózd W, Meszka J.
europepmc   +1 more source

Corrigendum: Computational modeling for antiarrhythmic drugs for atrial fibrillation according to genotype. [PDF]

Front Physiol, 2022
Hwang I, Jin Z, Park JW, Kwon OS, Lim B, Hong M, Kim M, Yu HT, Kim TH, Uhm JS, Joung B, Lee MH, Pak HN.   +12 more
europepmc   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Sex difference in atrial fibrillation recurrence after catheter ablation and antiarrhythmic drugs. [PDF]

Heart, 2023
Park YJ, Park JW, Yu HT, Kim TH, Uhm JS, Joung B, Joung B, Lee MH, Pak HN.   +8 more
europepmc   +1 more source

The ultrarapid delayed rectifier potassium current has important functional role in the repolarization reserve of canine and human ventricular muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial‐specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we challenged this prevailing concept and investigated the potential role of IKur in ventricular ...
Alaa Amin E. Abdelmagid, Aiman Saleh A. Mohammed, Gábor Mohácsi, Benjámin Paskuj, Gergő Bitay, Jakub Tomek, Sahil Dalal, Tamás Árpádffy‐Lovas, Vivien Demeter‐Haludka, István Koncz, Muhammad Naveed, László Virág, Norbert Nagy, András Varró, István Baczkó, Norbert Jost, Zsófia Kohajda, Leila Topal   +17 more
wiley   +1 more source

Antiarrhythmic drugs for cardiac arrest with a shockable rhythm and their effect on outcomes: a systematic review with meta-analysis. [PDF]

Europace
Schnaubelt S, Veigl C, Kornfehl A, Brock R, Tapinova K, Krammel M, Wildner B, Sossalla S, Niessner A, Sulzgruber P.   +9 more
europepmc   +1 more source