Results 61 to 70 of about 1,059,639 (249)
Medicinal Research Reviews, EarlyView.ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay +3 more
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Antiarrhythmic drugs and their action on ion channel [PDF]
, 2014 Department of Pharmacology and Clinical Pharmacology, State University of Medicine and Pharmacy “Nicolae Testemitanu”, Chişinău, Republic of MoldovaIntroduction: Antiarrhythmic drugs are preparations used in the treatment of cardiac arrhythmias ...
Draganel, Cristina, Draganel, Andrei
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Phytotherapy Research, EarlyView.Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli +6 more
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Cardiotoxicity of BRAF/MEK inhibitors
British Journal of Pharmacology, EarlyView.Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe +4 more
wiley +1 more source
Impact of controlling atrial fibrillation on outcomes relevant to the patient: focus on dronedarone
Patient Related Outcome Measures, 2012 C Anwar A Chahal, Omer Ali, Ross J Hunter, Richard J SchillingDepartment of Cardiology Research, St Bartholomew's Hospital, London, United KingdomAbstract: Atrial fibrillation (AF) is a substantial cause of mortality and morbidity in the Western ...
Chahal CAA +3 more
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Antiarrhythmic therapy in the treatment of atrial fibrillation: yesterday, today, tomorrow
Кардиоваскулярная терапия и профилактика, 2019 Atrial fibrillation (AF) is the most common heart rhythm disorder encountered in clinical practice. Each year, the number of patients with AF significantly increases.
V. I. Podzolkov, A. I. Tarzimanova
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Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang +4 more
wiley +1 more source
Hemodialysis International, EarlyView.ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra +2 more
wiley +1 more source
Antiarrhythmic drugs and polyneuropathy
, 1994 A total of 151 patients on chronic treatment with amiodarone and other antiarrhythmic drugs were subjected to standard clinical and electrophysiological investigation to assess the prevalence and specificity of polyneuropathy.
Bellocci, Fulvio, Fenici, Riccardo
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Present and future of antiarrhythmic therapy for atrial fibrillation: A review
Consilium MedicumDespite the emergence and active development of interventional methods for the treatment of arrhythmias, to date, the use of antiarrhythmic drugs to recover and maintain sinus rhythm is the most significant and in demand in patients with paroxysmal and ...
Aida I. Tarzimanova
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