Results 101 to 110 of about 8,495 (251)
The Journal of Physiology, EarlyView.Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial‐specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we challenged this prevailing concept and investigated the potential role of IKur in ventricular ...
Alaa Amin E. Abdelmagid +17 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa +6 more
wiley +1 more source
Statins and their antiarrhythmic activity
Кардиоваскулярная терапия и профилактика, 1970 Clinical trials of modern antiarrhythmics often demonstrate their ineffectiveness in life-threatening ventricular arrhythmias and sudden cardiac death (SCD), as well as inadequate pharmacological control in atrial fibrillation (AF).
N. Sh. Zagidullin +2 more
doaj
Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants
, 2017 Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about the binding ...
Denis B. Tikhonov, Boris S. Zhorov
core +1 more source
hERG1 channels and potential therapeutics for long QT syndrome
The Journal of Physiology, EarlyView.Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider +3 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 9, Page 2244-2261, 1 November 2026.Non‐small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations often exhibit significant tumor reduction following tyrosine kinase inhibitor (TKI) therapy. Residual tumors frequently remain, however, leading to drug resistance and disease progression.
Fedor Moiseenko +31 more
wiley +1 more source
Nursing in Critical Care, Volume 31, Issue 6, November 2026.ABSTRACT Background Palliative care in intensive care units should be planned jointly with patients and their families and documented in medical records. Proximity to death should prompt reassessment of the therapeutic strategy. Aim To analyse the interventions performed during the last 48 h in patients who died in the cardiac intensive care unit ...
Eduardo Tavares Gomes +2 more
wiley +1 more source
Journal of Arrhythmia, Volume 42, Issue 5, October 2026.Despite causing greater myocardial injury and hemolysis, pulsed field ablation induces significantly less systemic inflammation than radiofrequency ablation. This reduced inflammatory response is independently associated with a lower incidence of early atrial fibrillation recurrence.
Ken Watanabe +6 more
wiley +1 more source