Results 11 to 20 of about 1,123,987 (315)
Metal-Based Drugs, 1994 The antibacterial activity of silver has long been known and has found a variety of applications because its toxicity to human cells is considerably lower than to bacteria. The most widely documented uses are prophylactic treatment of burns and water disinfection. However, the mechanisms by which silver kills cells are not known.
Clement, Julia L., Jarrett, Penelope S.
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Unconventional Antibacterials and Adjuvants
Accounts of Chemical Research, 2021 The need for new classes of antibacterials is genuine in light of the dearth of clinical options for the treatment of bacterial infections. The prodigious discoveries of antibiotics during the 1940s to 1970s, a period wistfully referred to as the Golden Age of Antibiotics, have not kept up in the face of emergence of resistant bacteria in the past few ...
Mayland Chang +3 more
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Advances in preparation and application of antibacterial hydrogels
Journal of Nanobiotechnology, 2023 Bacterial infections, especially those caused by drug-resistant bacteria, have seriously threatened human life and health. There is urgent to develop new antibacterial agents to reduce the problem of antibiotics.
Yixin Tang +12 more
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The oxadiazole antibacterials [PDF]
Current Opinion in Microbiology, 2016 The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).
Shahriar Mobashery +2 more
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Antibiotics, 2020 As natural host defense compounds produced by numerous prokaryotic and eukaryotic life forms, antimicrobial peptides (AMPs) are now emerging as solid candidate chemotherapeutic drugs to fight against the various types of pathogenic Gram-positive and Gram-negative bacteria, especially those resistant to current antibiotics [...]
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'Evolution-Proofing' Antibacterials [PDF]
Evolution, Medicine, and Public Health, 2014 When antibiotics first came into use, they were so effective at curbing bacterial infections that it seemed the age-old battle of man vs. microbe would soon be at an end [1]. Eighty years and dozens of drugs later, we now know better. Following each new antibiotic’s launch, reports soon accumulated that once-treatable infections were becoming ...
Ross-Gillespie Adin, Kümmerli Rolf
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Structural understanding of SARS-CoV-2 virus entry to host cells
Frontiers in Molecular Biosciences, 2023 Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of fatalities worldwide.
Kim Le +7 more
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A Mini Review of Antibacterial Properties of ZnO Nanoparticles
Frontiers of Physics, 2021 The development of antibiotic resistance of bacteria is one of the most pressing problems in world health care. One of the promising ways to overcome microbial resistance to antibiotics is the use of metal nanoparticles and their oxides.
S. Gudkov +5 more
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Nature Communications, 2022 Carbamoyltransferases are a class of enzymes catalyzing carbamoylation of primary and secondary metabolites. Here, the authors show the molecular structure of the ansamycin-modifying carbamoyltransferase GdmN and repurpose the enzyme for the iterative ...
Jianhua Wei +9 more
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Applied Sciences, 2023 In this study, a nanocrystalline layer composed primarily of martensite phase was prepared on the surface of 304 stainless steel. Furthermore, the martensite phase content in the nanocrystalline layer was adjusted by heat treatment at 500 °C and 550 °C ...
Nengliang Huang +5 more
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