Results 21 to 30 of about 1,022,019 (313)

Acinetobacter baumannii Bloodstream Infections: A Nationwide Study in Israel

Microorganisms, 2023
Acinetobacter baumannii (Ab) bloodstream infections (BSIs) are a major public health concern and associated with high mortality. We describe the nationwide incidence, antimicrobial resistance, and mortality of Ab-BSI in Israel using laboratory-based BSI ...
Amir Nutman, Elizabeth Temkin, Liat Wullfhart, Vered Schechner, Mitchell J. Schwaber, Yehuda Carmeli   +5 more
doaj   +1 more source

OXA-900, a Novel OXA Sub-Family Carbapenemase Identified in Citrobacter freundii, Evades Detection by Commercial Molecular Diagnostics Tests

Microorganisms, 2021
Using whole-genome sequencing and cloning of the target gene, we identified blaOXA-900 carbapenemase, a novel blaOXA belonging to a distant and distinct sub-family of blaOXA-48-like. The plasmid-mediated gene was identified in a C.
Sammy Frenk, Nadya Rakovitsky, Hadas Kon, Reut Rov, Shirin Abramov, Mor Nadia Lurie-Weinberger, David Schwartz, Erica Pinco, Jonathan Lellouche, Yehuda Carmeli   +9 more
doaj   +1 more source

Occurrence, Typing, and Resistance Genes of ESBL/AmpC-Producing Enterobacterales in Fresh Vegetables Purchased in Central Israel

Antibiotics, 2023
Beta-lactam resistance can lead to increased mortality, higher healthcare expenses, and limited therapeutic options. The primary mechanism of beta-lactam resistance is the production of extended-spectrum beta-lactamases (ESBL) and AmpC beta-lactamases ...
Hadas Kon, Mor Lurie-Weinberger, Adi Cohen, Liat Metsamber, Alona Keren-Paz, David Schwartz, Yehuda Carmeli, Vered Schechner   +7 more
doaj   +1 more source

Vaccines in the fight against antimicrobial resistance – from evidence to policy - perspectives from South Africa

International Journal of Infectious Diseases
Introduction: The rising prevalence of drug-resistant infections presents a challenge to modern medicine by limiting life-saving therapeutic options, especially for those who cannot afford more expensive second-and third-line antibiotics, and ...
Dr Elloise Du Toit, Dr Erta Kalanxhi, Prof Adrian Brink, Ms Isabella Impalli   +3 more
doaj   +1 more source

Impact and Sustainability of Antibiotic Stewardship on Antibiotic Prescribing in Visceral Surgery

Antibiotics, 2021
Background: Antibiotic stewardship (AS) ward rounds are a core element in clinical care for surgical patients. Therefore, we aimed to analyze the impact of surgical AS ward rounds on antibiotic prescribing, and the sustainability of the effect after the ...
Magdalena Monika Gruber, Alexandra Weber, Jette Jung, Jens Werner, Rika Draenert   +4 more
doaj   +1 more source

Discovery of the fourth mobile sulfonamide resistance gene

Microbiome, 2017
Background Over the past 75 years, human pathogens have acquired antibiotic resistance genes (ARGs), often from environmental bacteria. Integrons play a major role in the acquisition of antibiotic resistance genes.
Mohammad Razavi, Nachiket P. Marathe, Michael R. Gillings, Carl-Fredrik Flach, Erik Kristiansson, D. G. Joakim Larsson   +5 more
doaj   +1 more source

Two pandemics: the COVID-19 pandemic’s impact on future AMR collaboration in Europe

Humanities & Social Sciences Communications, 2023
Based on 117 responses to a web survey in 29 European countries and interviews with bureaucrats in managerial positions, this paper investigates how people working professionally with antimicrobial resistance (AMR) assess the impact of the COVID-19 ...
Elina Lampi, Daniel Carelli, Jon Pierre, Björn Rönnerstrand   +3 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Are antibiotics naturally antibiotics?

Journal of Industrial Microbiology & Biotechnology, 2006
Antibiotics have been used for more than 50 years and are the cornerstone of infectious disease treatment; in addition, these low-molecular-weight bioactive compounds have been applied to many other therapeutic purposes. However, there is almost no information on the evolutionary biology or ecology of naturally occurring low-molecular-weight compounds.
openaire   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source