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ANTIBIOTIC RESISTANCE [PDF]

Critical Care Clinics, 1998
Antibiotic resistance is a worldwide concern. Over the past several decades, antibiotic resistance has increased to many respiratory pathogens as well as aerobic gram-negative bacilli. Recently, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) have become important hospital pathogens.
A J, Smith, K, Roy, J, Gibson, J, Bagg
  +11 more sources

Antibiotic resistance

Journal of Infection and Public Health, 2017
Antimicrobial resistance in bacterial pathogens is a challenge that is associated with high morbidity and mortality. Multidrug resistance patterns in Gram-positive and -negative bacteria are difficult to treat and may even be untreatable with conventional antibiotics.
Marianne Frieri, Krishan Kumar, Anthony Boutin   +2 more
  +8 more sources

Resistance-resistant antibiotics [PDF]

Trends in Pharmacological Sciences, 2014
New antibiotics are needed because drug resistance is increasing while the introduction of new antibiotics is decreasing. We discuss here six possible approaches to develop 'resistance-resistant' antibiotics. First, multitarget inhibitors in which a single compound inhibits more than one target may be easier to develop than conventional combination ...
Eric Oldfield, Xinxin Feng
openaire   +3 more sources

Phenotypic Resistance to Antibiotics [PDF]

Antibiotics, 2013
The development of antibiotic resistance is usually associated with genetic changes, either to the acquisition of resistance genes, or to mutations in elements relevant for the activity of the antibiotic. However, in some situations resistance can be achieved without any genetic alteration; this is called phenotypic resistance. Non-inherited resistance
Fernando Corona, Jose Martinez
openaire   +5 more sources

ANTIBIOTIC RESISTANCE

Journal of Research in Pharmacy, 2023
Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when the response of bacteria to medicines. Unfortunately nowadays the emergence of resistance among bacterial pathogens is a major public worldwide health problem.
openaire   +4 more sources

Mechanisms of antibiotic resistance [PDF]

Frontiers in Microbiology, 2015
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major ...
Lin, Jun, Nishino, Kunihiko, Roberts, Marilyn C., Tolmasky, Marcelo, Aminov, Rustam, Zhang, Lixin   +5 more
openaire   +6 more sources

Model Systems of Human Intestinal Flora, to Set Acceptable Daily Intakes of Antimicrobial Residues [PDF]

, 2000
The veterinary use of antimicrobial drugs in food producing animals may result in residues in food, that might modify the consumer gut flora. This review compares three model systems that maintain a complex flora of human origin: (i) human flora ...
Cemiglia CE, Corpet DE, Corpet DE Antibiotic residues and drug resistance in human intestinal flora, Corpet DE Antibiotic resistance from food, Corpet DE Current status of models for testing antibiotic residues, Freter R, Licht TR, Rollins LD, Tancrede C, Vollaard El   +9 more
core   +2 more sources

The impact of antibiotic use on transmission of resistant bacteria in hospitals: Insights from an agent-based model [PDF]

, 2018
Extensive antibiotic use over the years has led to the emergence and spread of antibiotic resistant bacteria (ARB). Antibiotic resistance poses a major threat to public health since for many infections antibiotic treatment is no longer effective ...
DRIVE-AB consortium, Elizabeth Temkin, Itzhak Benenson, Jonatan Almagor, Noga Fallach, Yehuda Carmeli   +5 more
core   +2 more sources

Tackling antibiotic resistance [PDF]

Nature Reviews Microbiology, 2011
The development and spread of antibiotic resistance in bacteria is a universal threat to both humans and animals that is generally not preventable but can nevertheless be controlled, and it must be tackled in the most effective ways possible. To explore how the problem of antibiotic resistance might best be addressed, a group of 30 scientists from ...
Bush, Karen, Courvalin, Patrice, Dantas, Gautam, Davies, Julian, Eisenstein, Barry, Huovinen, Pentti, Jacoby, George A., Kishony, Roy, Kreiswirth, Barry N., Kutter, Elizabeth, Lerner, Stephen A., Levy, Stuart, Lewis, Kim, Lomovskaya, Olga, Miller, Jeffrey H., Mobashery, Shahriar, Piddock, Laura J. V., Projan, Steven, Thomas, Christopher M., Tomasz, Alexander, Tulkens, Paul M., Walsh, Timothy R., Watson, James D., Witkowski, Jan, Witte, Wolfgang, Wright, Gerry, Yeh, Pamela, Zgurskaya, Helen I.   +27 more
openaire   +5 more sources

A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and ß-lactam resistance genes in the gut microbiota [PDF]

, 2014
peer-reviewedBackground: The potential for the human gut microbiota to serve as a reservoir for antibiotic resistance genes has been the subject of recent discussion. However, this has yet to be investigated using a rapid PCR-based approach.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, Ross, R Paul, STANTON, CATHERINE   +4 more
core   +1 more source