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Antibiotic Resistance

SSRN Electronic Journal, 2011
In this essay, written for the 30th Anniversary of Cardozo’s Arts and Entertainment Law Journal, I revisit the ruinous litigation strategy copyright owners pursued after Napster to secure control of the market for personal uses of copyrighted works, which I wrote about ten years ago in War Stories, 20 Cardozo Arts & Ent. L.J. 337 (2002).
openaire   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Use of a national repository of Fourier-transform infrared spectroscopy spectra enables fast detection of silent outbreaks and prevention of spread of new antibiotic-resistant sequence types

Antimicrobial Resistance and Infection Control
Background The reference microbiology laboratory of Israel’s National Institute for Antibiotic Resistance and Infection Control has established a national repository of isolates analyzed by Fourier-transform infrared (FTIR) spectroscopy and their spectra.
Mor N. Lurie-Weinberger, Elizabeth Temkin, Ophir Kastel, Moshe Bechor, Darya Bychenko-Banyas, Reut Efrati-Epchtien, Gabrielle D. Levi, Nadya Rakovitsky, Alona Keren-Paz, Yehuda Carmeli, The Antimicrobial Resistance Surveillance Group   +10 more
doaj   +1 more source

Carbapenem-resistant Acinetobacter baumannii carrier detection: a simple and efficient protocol

Microbiology Spectrum
Timely detection of carbapenem-resistant Acinetobacter baumannii (CRAB) carriers is essential to direct infection control measures. In this work, we aimed to develop a practical protocol to detect CRAB from screening samples. To choose a selective medium
Jonathan Lellouche, Alona Keren-Paz, Reut Rov, Reut Efrati Epchtien, Sammy Frenk, Amichay Hameir, Elizabeth Temkin, David Schwartz, Yehuda Carmeli   +8 more
doaj   +1 more source

In vivo Fitness of Acinetobacter baumannii Strains in Murine Infection Is Associated with International Lineage II-rep-2 and International Lineage III Clones Showing High Case Fatality Rates in Human Infections

Microorganisms, 2020
We previously reported that the 14-day case fatality rate (CFR) in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia varied between infecting clones.
Amir Nutman, Jonathan Lellouche, Ziv Lifshitz, Rivka Glick, Yehuda Carmeli   +4 more
doaj   +1 more source

Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance

Frontiers in Pharmacology
Antibiotics represent a frequently employed therapeutic modality for the management of bacterial infections across diverse domains, including human health, agriculture, livestock breeding, and fish farming.
Esraa M. Halawa, Mohamed Fadel, M. Al-Rabia, Ali Behairy, N. A. Nouh, M. Abdo, Rada Olga, Liana Fericean, A. Atwa, Mohammad El-Nablaway, Ahmed Abdeen   +10 more
semanticscholar   +1 more source

The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae

International Journal of Environmental Research and Public Health, 2020
Klebsiella pneumoniae is an important gram-negative opportunistic pathogen that causes a variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and liver abscesses.
Guoying Wang, Guo Zhao, Xiaoyu Chao, Longxiang Xie, Hong-ju Wang   +4 more
semanticscholar   +1 more source

How innate immunity proteins kill bacteria and why they are not prone to resistance [PDF]

, 2017
Recent advances on antibacterial activity of peptidoglycan recognition proteins (PGRPs) offer some insight into how innate immunity has retained its antimicrobial effectiveness for millions of years with no frequent emergence of resistant strains. First,
Dziarski, Roman, Gupta, Dipika
core   +1 more source

The evolution of antibiotic resistance [PDF]

Science, 2019
Clinically relevant evolution studies are needed to help fight the spread of antibiotic ...
MacLean, R. Craig, San Millan, Alvaro
openaire   +4 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source