Results 81 to 90 of about 2,829,471 (309)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Study of Molecular Mechanism of Antibiotic susceptibility against Polymicrobial Oral infection [PDF]

, 2010
Introduction- Antibiotic to treat dental caries infection are routinely prescribed. Bacteria have increased resistance to the currently recommended antibiotics.
Deepak Dwivedi
core  

Analysis of Antibiotic Resistance Genes (ARGs) across Diverse Bacterial Species in Shrimp Aquaculture [PDF]

There is little information available on antibiotic resistance (ABR) within shrimp aquaculture environments. The aim of this study was to investigate the presence of antibiotic resistance genes (ARGs) in shrimp farming operations in Atacames, Ecuador ...
Thomas VanderYacht, Salinas, Liseth, VanderYacht, Thomas, Tilden M. Mitchell, Graham, Jay P, Mitchell, Tilden M, Jay P. Graham, Ho, Tin, Trueba, Gabriel, Nikolina Walas, Gabriel Trueba, Liseth Salinas, Walas, Nikolina, Tin Ho   +13 more
core   +1 more source

An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages

Nature Communications
Plasmids carrying antibiotic resistance genes (ARG) are the main mechanism of resistance dissemination in Enterobacterales. However, the fitness-resistance trade-off may result in their elimination.
Pengdbamba Dieudonné Zongo, Nicolas Cabanel, Guilhem Royer, Florence Depardieu, Alain Hartmann, Thierry Naas, Philippe Glaser, Isabelle Rosinski-Chupin   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Monopoly Pricing of an Antibiotic Subject to Bacterial Resistance [PDF]

We develop a dynamic bio-economic model of bacterial resistance and disease transmission in which we characterize the pricing policy of a monopolist who is protected by a patent.
Markus Herrmann
core  

Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli [PDF]

, 2011
This work is also partially supported by BBSRC and the Scottish Funding Council (through SULSA)Antibiotic-resistant bacteria, particularly Gram negative species, present significant health care challenges.
H. Lou, M. Chen, Susan S Black, Beis Konstantinos, Bayley Hagan, Matteo Ceccarelli, Beis, Konstantinos, Bushell, SR, Ian R Booth, Victoria A. Bamford, A. Low, Alison S Low, Bamford Victoria A., I. R. Booth, Ceccarelli Matteo, Bushell, Simon R, Ceccarelli, Matteo, Ceccarelli, M, V. A. Bamford, J. H. Naismith, James H. Naismith, James H Naismith, Booth, Ian R, Bamford, Victoria A., Naismith James H., Lou Hubing, Booth Ian R., Low, AS, Black, Susan S, Low, Alison S, Naismith, James H, Tivadar Mach, S. S. Black, Naismith, JH, H. Bayley, Low, Alison S., Mach, T, Black, Susan S., Chen, M, Bushell Simon R., Simon R. Bushell, Susan S. Black, Low Alison S., Mach Tivadar, Beis, K, Hagan Bayley, Bushell, Simon R., Min Chen, Bamford, Victoria A, Bamford, VA, K. Beis, Lou, H, Ian R. Booth, S. R. Bushell, Mach, Tivadar, Konstantinos Beis, Lou, Hubing, Booth, IR, Black Susan S., Bayley, Hagan, Alison S. Low, Naismith, James H., T. Mach, Chen Min, Booth, Ian R., Simon R Bushell, Bayley, H, Chen, Min, Victoria A Bamford, Black, SS, Hubing Lou   +70 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance

, 2020
Antibiotic resistance is on the rise and has become one of the biggest public health challenges of our time. Bacteria are able to adapt to the selective pressure exerted by antibiotics in numerous ways, including the (over)expression of efflux pumps ...
Ebbensgaard, Anna Elisabeth, Anna Elisabeth Ebbensgaard, Jakob Frimodt-Møller, Frimodt-Møller, Jakob, Løbner-Olesen, Anders, Anders Løbner-Olesen   +5 more
core   +1 more source

Occurrence of Antibiotic Resistance in the Mediterranean Sea

, 2022
Seawater could be considered a reservoir of antibiotic-resistant bacteria and antibiotic resistance genes. In this communication, we evaluated the presence of bacterial strains in seawater collected from different coasts of Sicily by combining ...
Domenico Vicari, Rosa Alduina, Valeria Gargano, Antonino Gentile, Licia Pantano, Dario Savoca, Arianna Sucato, Delia Gambino   +7 more
core   +1 more source