Results 91 to 100 of about 2,829,471 (309)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Antibiotic Resistance in Aquatic Systems [PDF]

, 2017
Rivers, lakes and the ocean receive antibiotic resistance genes from human environments.
Pruden, Amy, Amy Pruden, Satoru Suzuki, Tong Zhang, Virta, Marko, Zhang, Tong, Suzuki, Satoru, Marko Virta   +7 more
core   +1 more source

Correlation between the Antibiotic Resistance Genes and Susceptibility to Antibiotics among the Carbapenem-Resistant Gram-Negative Pathogens

, 2021
In this study, the correlation between the antibiotic resistance genes and antibiotic susceptibility among the carbapenem-resistant Gram-negative pathogens (CRGNPs) recovered from patients diagnosed with acute pneumonia in Egypt was found. A total of 194
Khaled M. Aboshanab, Mahmoud A. Yassien, Ibrahim S. Yahia, Nadia A. Hassouna, Salma M. Abdelaziz   +4 more
core   +1 more source

Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets

BMC Genomics, 2017
Background Fluoroquinolones are broad-spectrum antibiotics used to prevent and treat a wide range of bacterial infections. Plasmid-mediated qnr genes provide resistance to fluoroquinolones in many bacterial species and are increasingly encountered in ...
Fredrik Boulund, Fanny Berglund, Carl-Fredrik Flach, Johan Bengtsson-Palme, Nachiket P. Marathe, DG Joakim Larsson, Erik Kristiansson   +6 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Surveillance of antibiotic resistance [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2015
Surveillance involves the collection and analysis of data for the detection and monitoring of threats to public health. Surveillance should also inform as to the epidemiology of the threat and its burden in the population. A further key component of surveillance is the timely feedback of data to stakeholders with a view to generating action aimed at ...
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin. [PDF]

, 2014
A yearlong study was performed to examine the effect of antibiotic administration on the bacterial gut flora. Gram-negative facultative anaerobic bacteria were recovered from the feces of healthy adult volunteers administered amoxicillin, minocycline or ...
Theresa eHunt, Javier eNunez-Garica, Miranda eKirchner, Miranda Kirchner, Yanmin Hu, Weile, J, Anthony Coates, Javier Nunez-Garcia, Card, R, Anjum, MF, Theresa Hunt, Roderick Card, Jan Weile, Kirchner, M, Mafura, M, Muriel eMafura, Hunt, T, Abu-Oun, M, Muna eAnjum, Roderick eCard, Muriel Mafura, Manal eAbuoun, Muna F. Anjum, Hu, Y, Nunez-Garcia, J, Yanmin eHu, Manal Abu-Oun, Jan eWeile, Anthony eCoates, Coates, A   +29 more
core   +1 more source

Resistance and Adaptation of Bacteria to Non-Antibiotic Antibacterial Agents: Physical Stressors, Nanoparticles, and Bacteriophages

, 2021
Antimicrobial resistance is a significant threat to human health worldwide, forcing scientists to explore non-traditional antibacterial agents to support rapid interventions and combat the emergence and spread of drug resistant bacteria.
Sylwia Karoń, Jan Paczesny, Kinga Matuła, Sada Raza   +3 more
core   +1 more source

A single amino acid substitution in SED-2 β-lactamase leads to increased inhibitor resistance and an extended substrate spectrum

Microbiology Spectrum
β-Lactamases are the leading mechanism of resistance to β-lactam antibiotics in Enterobacterales. Here, we report the detection and characteristics of SED-2, a new member of the Citrobacter sedlakii class A chromosomal β-lactamase SED family.
S. Laviad-Shitrit, H. Kon, D. Bychenko Banyas, R. Efrati Epchtien, M. Bechor, M. Lurie-Weinberger, E. Ben-Zeev, S. Frank, N. Rakovitsky, D. Schwartz, A. Keren-Paz, Y. Carmeli   +11 more
doaj   +1 more source