Results 11 to 20 of about 434,426 (194)

Incentivizing Narrow-Spectrum Antibiotic Development with Refunding [PDF]

Bull Math Biol 84, 59 (2022), 2020
The rapid rise of antibiotic resistance is a serious threat to global public health. Without further incentives, pharmaceutical companies have little interest in developing antibiotics, since the success probability is low and development costs are huge.
arxiv   +1 more source

Occurrence, Typing, and Resistance Genes of ESBL/AmpC-Producing Enterobacterales in Fresh Vegetables Purchased in Central Israel

Antibiotics, 2023
Beta-lactam resistance can lead to increased mortality, higher healthcare expenses, and limited therapeutic options. The primary mechanism of beta-lactam resistance is the production of extended-spectrum beta-lactamases (ESBL) and AmpC beta-lactamases ...
Hadas Kon, Mor Lurie-Weinberger, Adi Cohen, Liat Metsamber, Alona Keren-Paz, David Schwartz, Yehuda Carmeli, Vered Schechner   +7 more
doaj   +1 more source

OXA-900, a Novel OXA Sub-Family Carbapenemase Identified in Citrobacter freundii, Evades Detection by Commercial Molecular Diagnostics Tests

Microorganisms, 2021
Using whole-genome sequencing and cloning of the target gene, we identified blaOXA-900 carbapenemase, a novel blaOXA belonging to a distant and distinct sub-family of blaOXA-48-like. The plasmid-mediated gene was identified in a C.
Sammy Frenk, Nadya Rakovitsky, Hadas Kon, Reut Rov, Shirin Abramov, Mor Nadia Lurie-Weinberger, David Schwartz, Erica Pinco, Jonathan Lellouche, Yehuda Carmeli   +9 more
doaj   +1 more source

Antimicrobial Resistance: An Update from the Canadian Committee on Antibiotic Resistance

Canadian Journal of Infectious Diseases and Medical Microbiology, 2005
The present article is one of a series prepared by the Canadian Committee on Antibiotic Resistance (CCAR). These articles are designed to update readers on current activities intended to limit the development and transmission of antibiotic resistance
Canadian Committee on Antibiotic Resistance
doaj   +1 more source

Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes

Microbiome, 2019
Background Hospital wastewaters contain fecal material from a large number of individuals, of which many are undergoing antibiotic therapy. It is, thus, plausible that hospital wastewaters could provide opportunities to find novel carbapenemases and ...
Nachiket P. Marathe, Fanny Berglund, Mohammad Razavi, Chandan Pal, Johannes Dröge, Sharvari Samant, Erik Kristiansson, D. G. Joakim Larsson   +7 more
doaj   +1 more source

Two pandemics: the COVID-19 pandemic’s impact on future AMR collaboration in Europe

Humanities & Social Sciences Communications, 2023
Based on 117 responses to a web survey in 29 European countries and interviews with bureaucrats in managerial positions, this paper investigates how people working professionally with antimicrobial resistance (AMR) assess the impact of the COVID-19 ...
Elina Lampi, Daniel Carelli, Jon Pierre, Björn Rönnerstrand   +3 more
doaj   +1 more source

Carbapenem-Resistant Klebsiella pneumoniae Exhibiting Clinically Undetected Colistin Heteroresistance Leads to Treatment Failure in a Murine Model of Infection

mBio, 2018
Antibiotic resistance is a growing crisis and a grave threat to human health. It is projected that antibiotic-resistant infections will lead to 10 million annual deaths worldwide by the year 2050.
Victor I. Band, Sarah W. Satola, Eileen M. Burd, Monica M. Farley, Jesse T. Jacob, David S. Weiss   +5 more
doaj   +1 more source

Active surveillance for carbapenem-resistant Acinetobacter baumannii (CRAB) carriage

Microbiology Spectrum, 2023
Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat in healthcare settings, necessitating robust infection control measures. To identify the most effective sampling method for CRAB carriage detection, we conducted a comparative
Amir Nutman, Gabrielle D. Levi, Alona Keren-Paz, David Schwartz, Samira Masarwa, Vered Schechner, Yehuda Carmeli   +6 more
doaj   +1 more source

Unraveling the Diversity of Co-Colonization by CPE

Microorganisms, 2022
Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency
Gabrielle Levi, Mor Lurie-Weinberger, Alona Keren-Paz, Antoine O. Andremont, David Schwartz, Yehuda Carmeli   +5 more
doaj   +1 more source

Discovery of the fourth mobile sulfonamide resistance gene

Microbiome, 2017
Background Over the past 75 years, human pathogens have acquired antibiotic resistance genes (ARGs), often from environmental bacteria. Integrons play a major role in the acquisition of antibiotic resistance genes.
Mohammad Razavi, Nachiket P. Marathe, Michael R. Gillings, Carl-Fredrik Flach, Erik Kristiansson, D. G. Joakim Larsson   +5 more
doaj   +1 more source