Results 11 to 20 of about 854,778 (357)

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria [PDF]

Nature Reviews Microbiology, 2008
Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm.
Mathias Winterhalter
exaly   +2 more sources

ANTIBIOTIC RESISTANCE [PDF]

Critical Care Clinics, 1998
Antibiotic resistance is an increasing problem in many parts of the world. Antibiotic resistance has been associated with the use of some antibiotics but not with others. Due to the overuse of antibiotics with a high resistance potential, there has been an increase of resistance with certain bacteria, e.g., Staphylococcus aureus, Pseudomonas aeruginosa
A J, Smith, K, Roy, J, Gibson, J, Bagg
  +9 more sources

Resistance-resistant antibiotics [PDF]

Trends in Pharmacological Sciences, 2014
New antibiotics are needed because drug resistance is increasing while the introduction of new antibiotics is decreasing. We discuss here six possible approaches to develop 'resistance-resistant' antibiotics. First, multitarget inhibitors in which a single compound inhibits more than one target may be easier to develop than conventional combination ...
Eric, Oldfield, Xinxin, Feng
openaire   +2 more sources

Effect of temperature on Escherichia coli bloodstream infection in a nationwide population-based study of incidence and resistance

Antimicrobial Resistance and Infection Control, 2022
Background The incidence of Escherichia coli bloodstream infections (BSI) is high and increasing. We aimed to describe the effect of season and temperature on the incidence of E. coli BSI and antibiotic-resistant E.
Sarah F. Feldman, Elizabeth Temkin, Liat Wulffhart, Amir Nutman, Vered Schechner, Pnina Shitrit, Racheli Shvartz, Mitchell J. Schwaber, Yehuda Carmeli   +8 more
doaj   +1 more source

A framework for identifying the recent origins of mobile antibiotic resistance genes

Communications Biology, 2021
Ebmeyer and colleagues developed a genomic framework for identification and scrutiny of the origins of antibiotic resistance genes. Using data scoured from the literature and publicly available genomes, their results indicate that only 81% of previously ...
Stefan Ebmeyer, Erik Kristiansson, D. G. Joakim Larsson   +2 more
doaj   +1 more source

Discovery of a novel integron-borne aminoglycoside resistance gene present in clinical pathogens by screening environmental bacterial communities

Microbiome, 2020
Background New antibiotic resistance determinants are generally discovered too late, long after they have irreversibly emerged in pathogens and spread widely.
Maria-Elisabeth Böhm, Mohammad Razavi, Nachiket P. Marathe, Carl-Fredrik Flach, D. G. Joakim Larsson   +4 more
doaj   +1 more source

Antibiotic resistance

British Dental Journal, 2017
New antibiotics and further education about prescribing are needed.
Marianne Frieri, Krishan Kumar, Anthony Boutin   +2 more
openaire   +5 more sources

A Novel, Integron-Regulated, Class C β-Lactamase

Antibiotics, 2020
AmpC-type β-lactamases severely impair treatment of many bacterial infections, due to their broad spectrum (they hydrolyze virtually all β-lactams, except fourth-generation cephalosporins and carbapenems) and the increasing incidence of plasmid-
Maria-Elisabeth Böhm, Mohammad Razavi, Carl-Fredrik Flach, D. G. Joakim Larsson   +3 more
doaj   +1 more source

Model Systems of Human Intestinal Flora, to Set Acceptable Daily Intakes of Antimicrobial Residues [PDF]

, 2000
The veterinary use of antimicrobial drugs in food producing animals may result in residues in food, that might modify the consumer gut flora. This review compares three model systems that maintain a complex flora of human origin: (i) human flora ...
Cemiglia CE, Corpet DE, Corpet DE Antibiotic residues and drug resistance in human intestinal flora, Corpet DE Antibiotic resistance from food, Corpet DE Current status of models for testing antibiotic residues, Freter R, Licht TR, Rollins LD, Tancrede C, Vollaard El   +9 more
core   +2 more sources

The Association between Insertion Sequences and Antibiotic Resistance Genes

mSphere, 2020
Insertion sequences (ISs) are abundant mobile genetic elements on bacterial genomes, responsible for mobilization of many genes, including antibiotic resistance genes (ARGs).
Mohammad Razavi, Erik Kristiansson, Carl-Fredrik Flach, D. G. Joakim Larsson   +3 more
doaj   +1 more source