Results 41 to 50 of about 244,603 (309)

The microenvironment in antibiotic susceptibility testing

APMIS
Antibiotic susceptibility testing (AST) by agar diffusion has been repeatedly standardized and, in most cases, gives results which predict clinical success when antibiotic treatment is based on such results. The formation of the inhibition zone is due to a transition from planktonic to biofilm mode of growth.
Niels Høiby, Claus Moser, Oana Ciofu
openaire   +2 more sources

Rapid antimicrobial susceptibility testing in patients with bacteraemia due to Enterobacterales: an implementation study

Swiss Medical Weekly, 2023
AIMS OF THE STUDY: The goal of this descriptive study was to assess the performance as well as the extent of the clinical impact of rapid automated antimicrobial susceptibility testing in patients with bacteraemia due to Enterobacterales.
Claudine Reiber, Elias Bodendoerfer, Silvio D. Brugger, Nadia Eberhard, Eva Hitz, Daniel A. Hofmaenner, Sebastian Herren, Natalia Kolesnik-Goldmann, Stefano Manicini, Reinhard Zbinden, Annelies S. Zinkernagel, Barbara Hasse   +11 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Emerging technologies for rapid phenotypic antimicrobial susceptibility testing of clinical isolates of bacteria

Journal of Clinical Microbiology
Providing timely and accurate antimicrobial susceptibility testing (AST) results is a crucial component of clinical microbiology practice. Commercial rapid AST (RAST) is an emerging and quickly expanding area.
Jacob Rattin, Malcolm Boswell, Daniel Rhoads   +2 more
doaj   +1 more source

Current antibiotic sensitivity of Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss) farms from Southwestern Turkey

Journal of Agricultural Sciences, 2023
The continuity of antimicrobial resistance development in bacteria changes the type and dose of effective antibiotic treatments and makes routine monitoring studies necessary for successful control of bacterial diseases. This study was aimed to determine
Mesut Yılmaz, Tülin Arslan, Sabahat Selmin Sezgin, Ayşegül Kubilay   +3 more
doaj   +1 more source

Bacteriological Profile of Endotracheal Aspirates and their Antibiotic Susceptibility Pattern

, 2018
Early onset Ventilator associated pneumonia (VAP) is usually less severe, associated with a better prognosis, and is more likely caused by antibiotic- sensitive bacteria.
Sowmya G.S., Satya Sai B., Raghavendra Rao M., Pavithra N., Krishna Karthik M., Ranjitha Shankare Gowda   +5 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Rapid Bacterial Motility Monitoring Using Inexpensive 3D-Printed OpenFlexure Microscopy Allows Microfluidic Antibiotic Susceptibility Testing

Micromachines, 2022
Antibiotic susceptibility testing is vital to tackle the emergence and spread of antimicrobial resistance. Inexpensive digital CMOS cameras can be converted into portable digital microscopes using 3D printed x-y-z stages.
Tai The Diep, Sarah Helen Needs, Samuel Bizley, Alexander D. Edwards   +3 more
doaj   +1 more source

Assessment of antibiotic susceptibility of Legionella pneumophila isolated from water systems in Poland [PDF]

, 2017
Introduction and objective Several studies have reported therapy failures in patients with legionnaires’disease; however, antimicrobial resistance of clinical and environmental isolates of Legionella spp. has not yet been documented.
Sikora, Agnieszka, Bożena Krogulska, Iwona Gładysz, Kozioł-Montewka, Maria, Maria Kozioł-Montewka, Tomasz Stańczak, Wójtczak-Bobin, Małgorzata, Agnieszka Sikora, Gładysz, Iwona, Renata Matuszewska, Stańczak, Tomasz, Matuszewska, Renata, Małgorzata Wójtowicz-Bobin, Krogulska, Bożena   +13 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source