Results 101 to 110 of about 7,679,468 (314)

Antibiotic therapy as single treatment of acute appendicitis [PDF]

, 2009
BACKGROUND Appendectomy has been the established treatment of acute appendicitis during the last century, regarded as a simple and safe procedure, although hampered with postoperative complications and increased standard mortality.
Hansson, Jeanette, Hansson, Jeanette,, Solberg, Anna,, Khorram-Manesh, Amir,, Körner, Ulla,, Lundholm, Kent,   +5 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Patient Knowledge and Antibiotic Abuse: Evidence from an Audit Study in China [PDF]

We ask how patient knowledge of appropriate antibiotic usage affects both physicians prescribing behavior and the physician-patient relationship. We conduct an audit study in which a pair of simulated patients with identical flu-like complaints visits ...
Wei Zhang, Janet Currie, Wanchuan Lin
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Antibiotic resistance in the environment, with particular reference to MRSA [PDF]

, 2008
The introduction of β-lactam antibiotics (penicillins and cephalosporins) in the 1940s and 1950s probably represents the most dramatic event in the battle against infection in human medicine.
William Gaze, Gaze, William H., Hawkey, Peter, Peter Hawkey, Hawkey, P. M., O'Neill, Colette, O'Neill, C, Colette O'Neill, Elizabeth Wellington, Gaze, W, Wellington, E, Wellington, Elizabeth, Wellington, E. M. H., Gaze, William   +13 more
core   +1 more source

Drug-resistant Diarrheogenic Escherichia coli, Mexico

Emerging Infectious Diseases, 2005
Diarrheogenic Escherichia coli isolates from 45 (73%) of 62 hospitalized patients were resistant to common antimicrobial drugs. Sixty-two percent were multidrug resistant, and >70% were resistant to trimethoprim-sulfamethoxazole and ampicillin ...
Teresa Estrada-García, Jorge F. Cerna, Leova Paheco-Gil, Raúl F. Velázquez, Theresa J. Ochoa, Javier Torres, Herbert L. DuPont   +6 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

European antibiotic awareness day : a five-year perspective of Europe-wide actions to promote prudent use of antibiotics [PDF]

, 2014
Following the European Union (EU) Council Recommendation on prudent use of antimicrobial agents in human medicine in 2001, and the success of national campaigns, i.e.
Possenti, E., Goossens, H., Mancarella, Giovanni, European Antibiotic Awareness Day Collaborative Group, Mendez, A., Stryk, M., Zarb, Peter, Earnshaw, S., Gilbro, S., Albiger, B., European Antibiotic Awareness Day Technical Advisory Committee, Magiorakos, A. P., Todorova, B., Monnet, D. L.   +13 more
core   +1 more source

Diagnostic Accuracy of Pre-Biopsy MRI and CT Features for Predicting Vertebral Biopsy Yield in Suspected Vertebral Discitis Osteomyelitis: A Retrospective Single-Center Study

Diagnostics
Background/Objectives: Vertebral discitis osteomyelitis (VDO) is a serious infection involving the vertebral bodies and intervertebral discs, often requiring biopsy for pathogen identification. However, biopsy yields are variable, and guidance on patient
Amirmasoud Negarestani, Andrew Pasion, Caleb Bhatnagar, Zuhaib Khokhar, Ashima Kundu, Samantha Diulus, Jorge P. Parada, Emad Allam   +7 more
doaj   +1 more source