Results 91 to 100 of about 1,060,384 (315)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Lyme Disease Biobank: 10 years of 3 month follow-up visits from 2014 to 2023

Frontiers in Medicine
IntroductionLyme Disease Biobank (LDB) enrolls participants with signs and symptoms of early Lyme disease (LD) from endemic areas and makes samples available to researchers developing more accurate diagnostics. From 2014 to 23, 466 cases and 367 controls
Elizabeth J. Horn, George Dempsey, Anna M. Schotthoefer, Matthew McArdle, Allison F. Weber, Cathy De Luca, Bobbi S. Pritt, Elizabeth L. Maloney   +7 more
doaj   +1 more source

Physician dispensing and antibiotic prescriptions [PDF]

The regulation on prescribing and dispensing of antibiotics has a double purpose: to enhance access to antibiotic treatment and to reduce the inappropriate use of drugs. Nevertheless, incentives to dispensing physicians may lead to inefficiencies.
Giuliano Masiero, Karine Moschetti, Massimo Filippini   +2 more
core  

Phage therapy: An alternative to antibiotics in the age of multi-drug resistance. [PDF]

, 2017
The practice of phage therapy, which uses bacterial viruses (phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice.
Koskella, Britt, Lin, Derek, Lin, Henry
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections

Frontiers in Microbiology, 2019
Ascending Chlamydia trachomatis infection causes functional damage to the fallopian tubes, which may lead to ectopic pregnancy and infertility in women. Treatment failures using the standard regimens of doxycycline and azithromycin have been observed. We
Nathalie Loeper, Simon Graspeuntner, Svea Ledig, Inga Kaufhold, Friederike Hoellen, Andrea Schiefer, Andrea Schiefer, Beate Henrichfreise, Kenneth Pfarr, Kenneth Pfarr, Achim Hoerauf, Achim Hoerauf, Kensuke Shima, Jan Rupp, Jan Rupp   +14 more
doaj   +1 more source

Dispensing practices and antibiotic use [PDF]

The regulation on prescribing and dispensing of antibiotics has a double purpose: to enhance access to antibiotic treatment and to reduce the inappropriate use of drugs. Nevertheless, incentives to dispensing physicians may lead to inefficiencies.
Giuliano Masiero, Karine Moschetti, Massimo Filippini   +2 more
core  

Exploring the evidence base for national and regional policy interventions to combat resistance [PDF]

, 2015
The effectiveness of existing policies to control antimicrobial resistance is not yet fully understood. A strengthened evidence base is needed to inform effective policy interventions across countries with different income levels and the human health and
Aarestrup, Aarestrup, Ahuja, Aidara-Kane, Alimuddin Zumla, Allegranzi, Allegranzi, Amábile-Cuevas, Anthony D So, Anthony Kessel, Baertlein, Belongia, Belongia, Bushnell, Catley, Catley, Cheng, Coenen, Crowther-Gibson, Dagan, Datema, Davey, David L Heymann, De Boeck, Earnshaw, Emmeline J Buckley, Fazal K Dar, Finkelstein, Fätkenheuer, Gerber, Govin Permanand, Grave, Grave, Grazia Caleo, Grundmann, Hammerum, Hanne Bak Pedersen, Harbarth, Haydar Giha, Hennessy, Henry Lishi Li, Heuer, Holloway, Huttner, Huttner, Jack, Jasper Littmann, John-Arne Røttingen, Jørgen Schlundt, Kariuki, Katakweba, Khalid M Bindayna, Khan, Komolafe, Kümmerer, Little, Luoto, Mandal, Mark Rweyemamu, Marti, McNulty, Mishal Khan, Mitj, Mohammed Shahid, Moyane, Mshana, Nisi, Ogan, Okeke, Okeke, Okeke, Osman A Dar, Parry, Pittet, Pletz, Radley, Ranji, Richard Kock, Rumina Hasan, Silverman, Simonsen, Song, Speksnijder, Spurling, Stephan Harbarth, Vanden Eng, Vernet, Versporten, Versporten, Viberg, Vlieghe, Walt, Xiao, Zingg   +93 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Antibiotic treatment and susceptibility testing [PDF]

Journal of Clinical Pathology, 2005
A 60 year old tale The concept of attacking invading microorganisms without harming the host was first introduced by Paul Ehrlich. In 1910 he discovered “salvarsan”, which he announced as a magic bullet for the treatment of syphilis. Penicillin, produced by the fungus, Penicillium notatum , was first discovered by Alexander Fleming in 1928, purified ...
openaire   +2 more sources