Results 81 to 90 of about 7,679,468 (314)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Mortality Risk and Antibiotic Therapy for Patients with Infections Caused by Elizabethkingia Species—A Meta-Analysis

Medicina
Background and Objectives: Patients with infections caused by Elizabethkingia species require prompt identification and effective antibiotic treatment since these spp.
Chienhsiu Huang, Sufang Kuo, Lichen Lin
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Rare or Unusual Non-Fermenting Gram-Negative Bacteria: Therapeutic Approach and Antibiotic Treatment Options

Antibiotics
Non-fermenting Gram-negative bacteria (NFGNB) are a heterogeneous group of opportunistic pathogens increasingly associated with healthcare-associated infections.
Nicholas Geremia, Andrea Marino, Andrea De Vito, Federico Giovagnorio, Stefano Stracquadanio, Agnese Colpani, Stefano Di Bella, Giordano Madeddu, Saverio Giuseppe Parisi, Stefania Stefani, Giuseppe Nunnari   +10 more
doaj   +1 more source

Daptomycin and its immunomodulatory effect: consequences for antibiotic treatment of methicillin-resistant Staphylococcus aureus after heart surgery

Frontiers in Immunology, 2014
Infections by methicillin-resistant Staphylococcus aureus (MRSA) play an increasing role in the postoperative course. Although wound infections after cardiac surgery are rare, the outcome is limited by prolonged treatment with high mortality.
Theodor eTirilomis
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Monopoly Pricing of an Antibiotic Subject to Bacterial Resistance [PDF]

We develop a dynamic bio-economic model of bacterial resistance and disease transmission in which we characterize the pricing policy of a monopolist who is protected by a patent.
Markus Herrmann
core  

Antibiotic prescribing on two medical wards at St Luke’s Hospital : what scope for improvement? [PDF]

, 1996
Antibiotics are frequently prescribed drugs and form a significant part of the hospital budget. The literature suggests that prescribing is not without problems and may need constant review. We have no data relating to our hospital.
Fenech, Frederick F., Ebejer, Martin J., Schiavone, M., Vella, Patricia   +3 more
core  

Safety and efficacy of simplified antibiotic regimens for outpatient treatment of serious infection in neonates and young infants 0-59 days of age in Bangladesh: design of a randomized controlled trial. [PDF]

, 2013
BACKGROUND: Because access to care is limited in settings with high mortality, exclusive reliance on the current recommendation of 7-10 days of parenteral antibiotic treatment is a barrier to provision of adequate treatment of newborn infections. METHODS:
Ahmed, Wazir, Cousens, Simon, Black, Robert E, Baqui, Abdullah H, Roth, Daniel E, Mullany, Luke C, Saha, Samir Kumar, Mitra, Dipak, Shahidullah, Mohammad, Quasem, Iftekhar, Wall, Stephen, Williams, Emma K, Ahmed, ASM Nawshad Uddin, Brandes, Neal, Shamsuzzaman, AKM   +14 more
core   +1 more source

A Rare Case of Capnocytophaga canimorsus Meningitis in an Immunocompetent Patient: A Successful Outcome with a Short Course of Antibiotics

Case Reports in Neurology
Introduction: Capnocytophaga canimorsus is a Gram-negative bacterium found in the oral flora of dogs and cats, transmitted to humans through bites, licks, or scratches.
Adrienne Elisabeth van der Hoeven, Josephus Johannes Kerremans, Tjerk Joppe Lagrand   +2 more
doaj   +1 more source