Results 71 to 80 of about 7,679,468 (314)

Bloodstream Infection Caused by Raoultella ornithinolytica in a Chronic Hemodialysis Patient

Kidney and Dialysis
Bloodstream infections are a significant cause of morbidity and mortality among hemodialysis patients. These infections primarily involve Gram-positive bacteria and, less frequently, Gram-negative bacilli.
Matteo Righini, Martina Titone, Davide Martelli, Elisabetta Isola, Elena Tampieri, Romina Graziani, Chiara Valentini, Matteo De Liberali, Antonella Troiano, Mattia Monti, Vera Minerva, Lilio Hu, Brunilda Sejdiu, Olga Baraldi, Andrea Buscaroli   +14 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Artificial intelligence in optimizing antimicrobial therapy for gastro-renal disorders

Frontiers in Cellular and Infection Microbiology
Antimicrobial therapy remains central to the management of gastrointestinal and urinary tract infections, yet its effectiveness is increasingly compromised by antimicrobial resistance and antibiotic-induced microbiome disruption.
Oana Stoia, Paula Anderco, Teona Badiu, Samuel Bogdan Todor, Cristian Ichim   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Treatment failure in pneumonia: Impact of antibiotic treatment and cost analysis [PDF]

, 2012
The aim of this study was to investigate treatment failure (TF) in hospitalised community-acquired pneumonia (CAP) patients with regard to initial antibiotic treatment and economic impact.
Bauer, TT, Hauptmeier, BM, Ott, SR, Nüesch, E, Lepper, PM, Pletz, MW, Welte, T, Ernen, C, Hecht, J   +8 more
core   +1 more source

Peripheral Intravenous Therapy in Internal Medicine Department—Antibiotics and Other Drugs’ Consumption and Characteristics of Vascular Access Devices in 2-Year Observation Study

Antibiotics
Background: The aim of the study was to characterize the procedure of peripheral intravenous therapy (IT), including the characteristics of vascular access and related complications and qualitative and quantitative analyses of drug consumption. Materials
Piotr Piekiełko, Anna Mucha, Ewa Stawowczyk, Jadwiga Wójkowska-Mach   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The effect of a multispecies probiotic on the composition of the faecal microbiota and bowel habits in chronic obstructive pulmonary disease patients treated with antibiotics [PDF]

, 2009
Short-term antibiotic treatment profoundly affects the intestinal microbiota, which may lead to sustained changes in microbiota composition. Probiotics may restore such a disturbance.
Jonkers, D., Rombouts, F.M., Smidt, H., Pennings, H.J., Catherina J. M. Koning, Stockbrugger, R., Wouters, E., Hauke Smidt, Ellen Stobberingh, Daisy Jonkers, Reinhold Stockbrügger, Rombouts, F., Stockbrügger, R.W., Herman-Jan Pennings, Stobberingh, E., Koning, C.J., Frans Rombouts, Emiel Wouters   +17 more
core   +1 more source

Brucellar Endocarditis of the Tricuspid Valve: A Case Report and Review of the Literature

Pathogens
Brucellar endocarditis is a rare entity commonly described as a severe disease associated with high mortality and generally requiring valve surgery for cure.
Evangelo Boumis, Pierangelo Chinello, Vincenzo Galati, Simone Topino, Francesca Gavaruzzi, Stefania Cicalini   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source