Results 51 to 60 of about 7,679,468 (314)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Antibiotic resistance: how did we get here and what can we do? [PDF]

, 2013
Executive summary Does antibiotic resistance exist? Yes. It is a worsening phenomenon seen all over the world, including Australia. What are the implications of antibiotic resistance?
Sanjaya Senanayake
core  

Persistent Bacterial Infections, Antibiotic Treatment Failure, and Microbial Adaptive Evolution

, 2022
Antibiotic resistance is expected by the WHO to be the biggest threat to human health before 2050. In this overview, we argue that this prediction may in fact be too optimistic because it is often overlooked that many bacterial infections frequently ‘go ...
Søren Molin, Helle Krogh Johansen, Ruggero La Rosa, La Rosa, Ruggero, Molin, Søren, Johansen, Helle Krogh   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

"Practical Knowledge" and Perceptions of Antibiotics and Antibiotic Resistance Among Drugsellers in Tanzanian Private Drugstores. [PDF]

, 2010
Studies indicate that antibiotics are sold against regulation and without prescription in private drugstores in rural Tanzania. The objective of the study was to explore and describe antibiotics sale and dispensing practices and link it to drugseller ...
Mujinja, Phare, Tomson, G., Göran Tomson, Tomson, Göran, Kalala, W., Viberg, Nina, Kalala, Willbrord, Viberg, N., Lundborg Cecilia, Cecilia Stålsby Lundborg, Willbrord Kalala, Lundborg, Cecilia Stålsby, Mujinja, P., Lundborg, C.S., Phare Mujinja, Nina Viberg, Mujinja Phare, Viberg Nina, Tomson Göran, Kalala Willbrord   +19 more
core   +2 more sources

Coccidioidomycosis and Host Microbiome Interactions: What We Know and What We Can Infer from Other Respiratory Infections

Journal of Fungi, 2023
Between 70 and 80% of Valley fever patients receive one or more rounds of antibiotic treatment prior to accurate diagnosis with coccidioidomycosis. Antibiotic treatment and infection (bacterial, viral, fungal, parasitic) often have negative implications ...
Susana Tejeda-Garibay, Katrina K. Hoyer
doaj   +1 more source

Antibiotic treatment of sepsis

Medical Clinics of North America, 1995
Early, appropriate antibiotic therapy is critical to the treatment of the septicemic patient. The degree of organ dysfunction, underlying medical conditions, and physiologic abnormalities are important prognostic factors but are not important in initial antibiotic selection.
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Active trachoma and ocular Chlamydia trachomatis infection in two Gambian regions: on course for elimination by 2020? [PDF]

, 2009
BACKGROUND: Trachoma has been endemic in The Gambia for decades. National trachoma control activities have been in place since the mid-1980's, but with no mass antibiotic treatment campaign.
Chrissy H Roberts, Sarr Isatou, Esther Aryee, Edwards Tansy, Sillah Ansumana, Harding-Esch, Emma M, Sillah, Ansumana, Martin J Holland, Bailey Robin L., Molina, Sandra, Edwards, Tansy, Harding-Esch Emma M., Sandra Molina, David C W Mabey, Emma M Harding-Esch, Isatou Sarr, Snell Paul, Paul Snell, Tansy Edwards, Ansumana Sillah, Mabey David C. W., Roberts Chrissy H., Robin L Bailey, Bailey, Robin L, Holland, Martin J, Snell, Paul, Roberts, Chrissy H, Aryee Esther, Sarr, Isatou, Molina Sandra, Holland Martin J., Mabey, David CW, Aryee, Esther   +32 more
core   +1 more source

A Novel Disease (Water Bubble Disease) of the Giant Freshwater Prawn Macrobrachium rosenbergii Caused by Citrobacter freundii: Antibiotic Treatment and Effects on the Antioxidant Enzyme Activity and Immune Responses

Antioxidants, 2022
The giant freshwater prawn, Macrobrachium rosenbergii, is an important and economical aquaculture species widely farmed in tropical and subtropical areas of the world.
Caiyuan Zhao, Huagen Wen, Shengsheng Huang, Shaoping Weng, Jianguo He   +4 more
doaj   +1 more source