Results 51 to 60 of about 1,060,384 (315)

Reducing Antibiotic Use in Pediatric Upper Respiratory Infection: A Multifaceted Parent-Clinician Approach [PDF]

, 2017
The goal of this QI initiative was to decrease inappropriate antibiotic for the treatment of pediatric upper respiratory infection (URI) in the retail clinic setting. The approach included the use of a protocol to treat viral upper respiratory illness, a
Lucas, Sydnee H, DNP, APRN, Thompson, Sydney, DNP, ARNP, FNP-BC   +1 more
core   +1 more source

Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population [PDF]

, 2020
Since antibiotic resistance is a major threat to global health, recent observations that the traditional test of minimum inhibitory concentration (MIC) is not informative enough to guide effective antibiotic treatment are alarming.
Debski, Pawel R., Garstecki, Piotr, Horka, Michal, Makuch, Karol, Pacocha, Natalia, Postek, Witold, Ruszczak, Artur, Scheler, Ott, Smolander, Olli-Pekka, Sozański, Krzysztof   +9 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Gut Microbiota Is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San

Metabolites, 2020
Accumulating evidence highlights the link between gut microbiota and depression. As an antidepressant herbal drug in clinic, Chaihu-Shu-Gan-San (CSGS) has also been used in China for the treatment of various gastrointestinal disorders.
Meng Yu, Hong-Mei Jia, Tao Zhang, Hai Shang, Hong-Wu Zhang, Li-Yan Ma, Zhong-Mei Zou   +6 more
doaj   +1 more source

Challenges in the Implementation of the NeoOBS Study, a Global Pragmatic Observational Cohort Study, to Investigate the Aetiology and Management of Neonatal Sepsis in the Hospital Setting

Antibiotics, 2023
Neonatal sepsis is a significant cause of mortality and morbidity in low- and middle-income countries. To deliver high-quality data studies and inform future trials, it is crucial to understand the challenges encountered when managing global multi-centre
Amy Riddell, Aislinn Cook, Nathalie Khavessian, Sally Ellis, Davide Bilardi, Erika Correia, Tomislav Kostyanev, Alessandra Nardone, Neal Russell, Tuba Vilken, Wolfgang Stohr, Bethou Adhisivam, Iana Rosa Alves de Moraes, Nawshad Uddin Ahmed, Adrie Bekker, Eitan Naaman Berezin, Suppawat Boonkasidecha, Cristina G. Carvalheiro, Prachi Chauhan, Sara Chiurchiù, Elisavet Chorafa, Angela Dramowski, Madhusudhan DS, Jinxing Feng, Shengnan Jia, Yuan Kong, Mary Kyohere, Angeliki Kontou, Sorasak Lochindarat, Maia De Luca, Aripfani Mphaphuli, Marisa M. Mussi-Pinhata, Sheila Murunga, Firdose Lambey Nakwa, Sushma Nangia, Erinah Nassolo, Ngoc Thi Bin Hoang, Christina W. Obiero, Linus Olson, Wang Ping, Nishad Plakkal, Priyanka Prasad, Kanchana Preedisripipat, Sheikh Wasik Rahman, Tiffany Seef, Pra-ornsuda Sukrakanchana, Reenu Thomas, Zhang Yu, Qiaoru Zhang, A. Sarah Walker, Julia Bielicki, Paul T. Heath, Michael Sharland, Tatiana Munera-Huertas   +53 more
doaj   +1 more source

Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms. [PDF]

, 2020
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S.
Allan, RN, Angus, EM, Coates, ARM, Frapwell, CJ, Howlin, RP, Hu, Y, Skipp, PJ, Webb, JS   +7 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Effect of Doxycycline Use in the Early Broiler Production Cycle on the Microbiome

Frontiers in Microbiology, 2022
16S rRNA amplicon sequencing was used to investigate changes in the broiler gastrointestinal tract (GIT) microbiota throughout the rearing period and in combination with antibiotic treatment.
Genevieve Greene, Genevieve Greene, Leonard Koolman, Paul Whyte, Catherine Burgess, Helen Lynch, Helen Lynch, Aidan Coffey, Brigid Lucey, Lisa O’Connor, Declan Bolton   +10 more
doaj   +1 more source

Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections:a multi-country medical chart review in Europe [PDF]

, 2014
BACKGROUND: Patient-related (demographic/disease) and treatment-related (drug/clinician/hospital) characteristics were evaluated as potential predictors of healthcare resource use and opportunities for early switch (ES) from intravenous (IV)-to-oral ...
A Gray, AD Tice, AL Chapman, BA Cunha, BA Lipsky, C Eckmann, C Eckmann, Caitlyn T Solem, Christian Eckmann, Cynthia Macahilig, D Nathwani, D Nathwani, DA Goff, Damien Simoneau, Dilip Nathwani, HS Sader, HT Hatoum, J Edelsberg, Jennifer M Stephens, Jim Z Li, KB Bamford, M Borner, M Desai, M Dryden, M Hensher, P Mladovsky, PC Matthews, RA Seaton, Richard Chambers, S Leekha, S Parodi, SC Lim, Seema Haider, Shelby Corman, TH Dellit, Wendy Lawson   +35 more
core   +4 more sources

Topical Antibiotic Treatment in Dermatology

Antibiotics, 2023
Many indications in dermatology can be effectively managed with topical antibiotics, including acne vulgaris, wound infections, secondarily infected dermatitis, and impetigo. Dermatologists must be familiar with the wide spectrum of topical antibiotics available, including indications, mechanisms of action, adverse events, and spectra of activity ...
Dallo, Matthew, Patel, Kavina, Hebert, Adelaide A   +2 more
openaire   +4 more sources