Results 61 to 70 of about 7,679,468 (314)

When antibiotic treatment fails [PDF]

Intensive Care Medicine, 2017
n ...
Bassetti M., Montero J. G., Paiva J. A.
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Short therapy in a septic arthritis of the neonatal hip

Pediatric Reports, 2019
Septic arthritis (SA) is a serious joint infection associated with significant morbidity that can cause permanent damage with articular cartilage destruction, osteonecrosis and lifelong deformities if not diagnosed and treated promptly.
Antonio Gatto, Ilaria Lazzareschi, Roberta Onesimo, Rossella Iannotta, Donato Rigante, Lavinia Capossela, Simona Filoni, Piero Valentini   +7 more
doaj   +1 more source

The impact of COVID-19 on primary health care and antibiotic prescribing in rural China: qualitative study

BMC Health Services Research, 2021
Background In China, the primary health care (PHC) system has been designated responsible for control and prevention of COVID-19, but not treatment. Suspected COVID-19 cases presenting to PHC facilities must be transferred to specialist fever clinics ...
Tingting Zhang, Xingrong Shen, Rong Liu, Linhai Zhao, Debin Wang, Helen Lambert, Christie Cabral   +6 more
doaj   +1 more source

Evaluation of a Dietary Grape Extract on Oxidative Status, Intestinal Morphology, Plasma Acute-Phase Proteins and Inflammation Parameters of Weaning Piglets at Various Points of Time

Antioxidants, 2022
Reports of the underlying mechanisms of dietary grape extract (GE) in overcoming weaning challenges in piglets have been partly inconsistent. Furthermore, evaluations of the effects of GE at weaning in comparison to those of widely used therapeutic ...
Emina Rajković, Christiane Schwarz, Stefan Bruno Kapsamer, Karl Schedle, Nicole Reisinger, Caroline Emsenhuber, Vladimira Ocelova, Nataliya Roth, Dörte Frieten, Georg Dusel, Martin Gierus   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Study of Molecular Mechanism of Antibiotic susceptibility against Polymicrobial Oral infection [PDF]

, 2010
Introduction- Antibiotic to treat dental caries infection are routinely prescribed. Bacteria have increased resistance to the currently recommended antibiotics.
Deepak Dwivedi
core  

Empiric antibiotic treatment of lesser pelvis inflammatory diseases at the hospital stage

Гинекология, 2013
Acute salpingo-oophoritis treatment is based on the general principles of infectious pathology management and implies appropriate antibacterial therapy, which is often empiric.
E V Eliseeva, I P Torgovitskaya, A V Tyrtyshnikova, Yu V Feoktistova, E A Poddubny, L M Grekhneva   +5 more
doaj  

The effect of perinatal antibiotic prophylaxis on an early onset of symptomatic infections in newborns

Pielęgniarstwo XXI Wieku, 2018
THE EFFECT OF PERINATAL ANTIBIOTIC PROPHYLAXIS ON AN EARLY ONSET OF SYMPTOMATIC INFECTIONS IN NEWBORNS Aim. The aim of the study was to evaluate the effectiveness of preventive perinatal antibiotic therapy on the occurrence of an early-symptomatic ...
Sławomir Szymański, Katarzyna Szczerba, Violetta Konstanty-Kurkiewicz   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source