Results 41 to 50 of about 7,679,468 (314)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Rare Case of Staphylococcus Caprae Periprosthetic Hip Infection with Unusual Clinical Presentation

Journal of Orthopaedic Case Reports
Introduction: Total hip arthroplasty (THA) surgeries are rapidly increasing due to an aging population, leading to an increase in degenerative hip osteoarthritis. However, 1% of these patients go through prosthetic joint infection (PJI), which gives rise
Daniele Grassa, Francesco Cavola, Alessandro Giuliani, Rashma Rajeev, Alessandro Singlitico, Ivan De Martino   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Treatment of uncomplicated UTI in males: a systematic review of the literature

BJGP Open, 2021
Background: Urinary tract infections (UTIs) affect around 20% of the male population in their lifetime. The incidence of UTIs in men in the community is 0.9–2.4 cases per 1000 aged
Karen Farrell, Meera Tandan, Virginia Hernandez Santiago, Ildiko Gagyor, Anja Maria Braend, Marius Skow, Ingvild Vik, Filip Jansaaker, Gail Hayward, Akke Vellinga   +9 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The role of antibiotics in the treatment of chronic prostatitis: A consensus statement [PDF]

, 1998
Practical guidelines for the diagnosis and treatment of chronic prostatitis are presented. Chronic prostatitis is classified as chronic bacterial prostatitis (culture-positive) and chronic inflammatory prostatitis (culture-negative). If chronic bacterial
Lobel, B, van Cangh, PJ, Hofstetter, A, Redorta, JP, Johansen, TEB, Naber, Kurt G., Grüneberg, R. N., Guibert, J, Naber, KG, Guibert, J., Palou Redorta, J., Lobel, B., Hofstetter, Alfons, Bjerklund Johansen, T. E., Gruneberg, RN, Cangh, P. J. van   +15 more
core   +1 more source

Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study [PDF]

, 2017
Felix Greimel,1 Christine Scheuerer,1 Andre Gessner,2 Michaela Simon,2 Thomas Kalteis,1 Joachim Grifka,1 Achim Benditz,1 Hans-Robert Springorum,1 Jens Schaumburger1 1Department of Orthopedics, University Medical Center Regensburg, Asklepios ...
Simon M, Gessner A, Kalteis T, Springorum HR, Greimel F, Schaumburger J, Scheuerer C, Benditz A, Grifka J   +8 more
core   +2 more sources

The principles of curative antibiotic treatments

Infectious Diseases Now, 2023
Knowledge of infectious diseases and their treatments is constantly evolving. New infectious agents are regularly discovered, due mainly to improvement of identification techniques, especially the development of molecular biology and mass spectrometry.
Robert Cohen, Emmanuel Grimprel, Alexis Rybak, Isabelle Hau, Fouad Madhi, Naim Ouldali, Josette Raymond   +6 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infections. [PDF]

, 2010
In a clinical infection, multiplying and non-multiplying bacteria co-exist. Antibiotics kill multiplying bacteria, but they are very inefficient at killing non-multipliers which leads to slow or partial death of the total target population of microbes in
Liu, Y, Alireza Shamaei-Tousi, Coates Anthony, Shamaei-Tousi, A, Hu, Y, Liu Yingjun, Yanmin Hu, Hu Yanmin, Yingjun Liu, Shamaei-Tousi Alireza, Anthony Coates, Coates, A   +11 more
core   +2 more sources